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Professor Shankar Balasubramanian FMedSci FRS

Portrait of sb10031

Nucleic acids are fundamental to life. Our research is focused on the chemical biology of nucleic acids, and employs the principles of chemistry and the molecular sciences to address questions of importance in biology and medicine. Projects are inherently interdisciplinary and will provide scope for a diversity of intellectual and experimental approaches that include: organic synthesis, biophysics, molecular and cellular biology and genomics. Our scientific goals are problem-driven, which constantly raises the need to invent new methodology.


A major interest is to elucidate and manipulate mechanisms that control the expression of genes (either transcription, or translation). We are particularly interested in the role of non-canonical nucleic acid structures that control gene expression (e.g. G-quadruplexes, micro RNA and RNA structures in the 5' untranslated regions of mRNAs). Our goal is to design and synthesise small organic molecules that target such structures and alter the expression of certain genes of interest. Such small molecule gene regulators are valuable tools to study mechanisms in biology and will also open up new approaches for therapeutics and molecular medicine, particularly for diseases characterized by aberrant expression of certain genes (e.g. various cancers).


Our fundamental science will inevitably create opportunities for translation and commercialisation. One such example was our invention (with Professor David Klenerman) of new DNA sequencing technology ("Solexa sequencing") that was commercialised as a Cambridge University spinout company (now part of Illumina Inc.) and is used routinely for applications in genomics, including human genome sequencing. 

To hear Shankar Balasubramanian discuss some of the group's research click here:


Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing.
HL Lightfoot, EA Miska, S Balasubramanian
– Org Biomol Chem
G-quadruplex structures mark human regulatory chromatin.
R Hänsel-Hertsch, D Beraldi, SV Lensing, G Marsico, K Zyner, A Parry, M Di Antonio, J Pike, H Kimura, M Narita, D Tannahill, S Balasubramanian
– Nature Genetics
rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome.
CK Kwok, G Marsico, AB Sahakyan, VS Chambers, S Balasubramanian
– Nature methods
DSBCapture: in situ capture and sequencing of DNA breaks
SV Lensing, G Marsico, R Hänsel-Hertsch, EY Lam, D Tannahill, S Balasubramanian
– Nature methods
An Epigenetics-Inspired DNA-Based Data Storage System
C Mayer, GR McInroy, P Murat, P Van Delft, S Balasubramanian
– Angew Chem Int Ed Engl
Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA.
CK Kwok, AB Sahakyan, S Balasubramanian
– Angew Chem Int Ed Engl
Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications
A Cording, M Gormally, PJ Bond, M Carrington, S Balasubramanian, EA Miska, B Thomas
– RNA biology
Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes.
OS Walker, SJ Elsässer, M Mahesh, M Bachman, S Balasubramanian, JW Chin
– Journal of the American Chemical Society
Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases
AB Sahakyan, S Balasubramanian
– BMC genomics
In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine.
M Iurlaro, GR McInroy, HE Burgess, W Dean, E-A Raiber, M Bachman, D Beraldi, S Balasubramanian, W Reik
– Genome Biol
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Research Interest Group

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01223 336347

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