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Professor Shankar Balasubramanian FMedSci FRS

Portrait of sb10031

Nucleic acids are fundamental to life. Our research is focused on the chemical biology of nucleic acids, and employs the principles of chemistry and the molecular sciences to address questions of importance in biology and medicine. Projects are inherently interdisciplinary and will provide scope for a diversity of intellectual and experimental approaches that include: organic synthesis, biophysics, molecular and cellular biology and genomics. Our scientific goals are problem-driven, which constantly raises the need to invent new methodology.

 

A major interest is to elucidate and manipulate mechanisms that control the expression of genes (either transcription, or translation). We are particularly interested in the role of non-canonical nucleic acid structures that control gene expression (e.g. G-quadruplexes, micro RNA and RNA structures in the 5' untranslated regions of mRNAs). Our goal is to design and synthesise small organic molecules that target such structures and alter the expression of certain genes of interest. Such small molecule gene regulators are valuable tools to study mechanisms in biology and will also open up new approaches for therapeutics and molecular medicine, particularly for diseases characterized by aberrant expression of certain genes (e.g. various cancers).

 

Our fundamental science will inevitably create opportunities for translation and commercialisation. One such example was our invention (with Professor David Klenerman) of new DNA sequencing technology ("Solexa sequencing") that was commercialised as a Cambridge University spinout company (now part of Illumina Inc.) and is used routinely for applications in genomics, including human genome sequencing. 

To hear Shankar Balasubramanian discuss some of the group's research click here:

 http://www.sms.cam.ac.uk/media/1111642

Publications

Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA.
CK Kwok, AB Sahakyan, S Balasubramanian – Angew Chem Int Ed Engl (2016)
Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications
A Cording, M Gormally, PJ Bond, M Carrington, S Balasubramanian, EA Miska, B Thomas – RNA biology (2016) 1
Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes.
OS Walker, SJ Elsässer, M Mahesh, M Bachman, S Balasubramanian, JW Chin – Journal of the American Chemical Society (2016) 138, 718
In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine.
M Iurlaro, GR McInroy, HE Burgess, W Dean, EA Raiber, M Bachman, D Beraldi, S Balasubramanian, W Reik – Genome Biol (2016) 17, 141
Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases
AB Sahakyan, S Balasubramanian – BMC genomics (2016) 17, 225
Molecular signatures of plastic phenotypes in two eusocial insect species with simple societies
S Patalano, A Vlasova, C Wyatt, P Ewels, F Camara, PG Ferreira, CL Asher, TP Jurkowski, A Segonds-Pichon, M Bachman, I González-Navarrete, AE Minoche, F Krueger, E Lowy, M Marcet-Houben, JL Rodriguez-Ales, FS Nascimento, S Balasubramanian, T Gabaldon, JE Tarver, S Andrews, H Himmelbauer, WO Hughes, R Guigó, W Reik, S Sumner – Proceedings of the National Academy of Sciences of the United States of America (2015) 112, 13970
5-Formylcytosine can be a stable DNA modification in mammals
M Bachman, S Uribe-Lewis, X Yang, HE Burgess, M Iurlaro, W Reik, A Murrell, S Balasubramanian – Nature Chemical Biology (2015) 11, 555
High-throughput sequencing of DNA G-quadruplex structures in the human genome
VS Chambers, G Marsico, JM Boutell, M Di Antonio, GP Smith, S Balasubramanian – Nature Biotechnology (2015) 33, 877
FOXM1 binds directly to non-consensus sequences in the human genome
DA Sanders, MV Gormally, G Marsico, D Beraldi, D Tannahill, S Balasubramanian – Genome Biol (2015) 16, 130
5-Formylcytosine can be a stable DNA modification in mammals
M Bachman, S Uribe-Lewis, X Yang, HE Burgess, M Iurlaro, W Reik, A Murrell, S Balasubramanian – Nature Chemical Biology (2015) 11, 555
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Research Interest Group

Telephone number

01223 336347

Email address

sb10031@cam.ac.uk