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Yusuf Hamied Department of Chemistry

 

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Non-internalising antibody-drug conjugates.
N Ashman, JD Bargh, DR Spring
– Chemical Society reviews
(2022)
51,
9182
(doi: 10.1039/d2cs00446a)
A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action
P Brear, C De Fusco, EL Atkinson, J Iegre, NJ Francis-Newton, AR Venkitaraman, M Hyvönen, DR Spring
– RSC Med Chem
(2022)
13,
1420
(doi: 10.1039/d2md00161f)
Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy.
AR Hanby, SJ Walsh, AJ Counsell, N Ashman, KT Mortensen, JS Carroll, DR Spring
– Chemical communications (Cambridge, England)
(2022)
58,
9401
(doi: 10.1039/d2cc02515a)
All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading
FM Dannheim, SJ Walsh, CT Orozco, AH Hansen, JD Bargh, SE Jackson, NJ Bond, JS Parker, JS Carroll, DR Spring
– Chemical Science
(2022)
13,
8781
(doi: 10.1039/d2sc02198f)
Reconstructing the history of helminth prevalence in the UK
H Ryan, PG Flammer, R Nicholson, L Loe, B Reeves, E Allison, C Guy, IL Doriga, T Waldron, D Walker, C Kirchhelle, G Larson, AL Smith
– PLoS neglected tropical diseases
(2022)
16,
e0010312
(doi: 10.1371/journal.pntd.0010312)
Development of small cyclic peptides targeting the CK2α/β interface.
EL Atkinson, J Iegre, C D'Amore, P Brear, M Salvi, M Hyvönen, DR Spring
– Chem Commun (Camb)
(2022)
58,
4791
(doi: 10.1039/d2cc00707j)
Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability.
SJ Walsh, S Omarjee, FM Dannheim, D-L Couturier, D Bexheti, L Mendil, G Cronshaw, T Fewster, C Gregg, C Brodie, JL Miller, R Houghton, JS Carroll, DR Spring
– Chemical Communications
(2022)
58,
1962
(doi: 10.1039/d1cc06766d)
Correction: The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions.
BH Gan, J Gaynord, SM Rowe, T Deingruber, DR Spring
– Chem Soc Rev
(2022)
51,
792
(doi: 10.1039/d1cs90109e)
Energetics of lipid transport by the ABC transporter MsbA is lipid dependent.
D Guo, H Singh, A Shimoyama, C Guffick, Y Tang, SM Rowe, T Noel, DR Spring, K Fukase, HW van Veen
– Communications Biology
(2021)
4,
1379
(doi: 10.1038/s42003-021-02902-8)
Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides.
G Fumagalli, RJ Carbajo, JWM Nissink, J Tart, R Dou, AP Thomas, DR Spring
– Journal of Medicinal Chemistry
(2021)
64,
17287
(doi: 10.1021/acs.jmedchem.1c01334)
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College

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    About the University

    Research at Cambridge