skip to content
 

Professor Christopher Abell FRS FMedSci

Portrait of ca26

One of the biggest challenges in biological chemistry is the design of small molecules that interact selectively with macromolecules. We are pioneering the development of the use of fragments to address this challenge. This approach involves close synergistic interaction between synthetic organic chemistry, biophysics and structural biology. We are using fragment-based methods to identify inhibitors of enzymes from Mycobacterium tuberculosis, and to develop small molecules that modulate protein-protein interactions. We are also keen to explore new applications for fragments e.g. to identify molecules that modulate the activity of riboswitches, and to assign function to orphan proteins.

Our second major area of research is to develop the use of microdroplets in microfluidics as a novel experimental platform for biological chemistry. This research is highly interdisciplinary and involves biological chemistry, microfluidics, nanofabrication, laser spectroscopy and mass spectrometry. We are particularly interested in looking at cells in droplets, e.g. bacteria to study quorum sensing, algae for bio-fuel development.

 

For a full list of publications, see http://www-abell.ch.cam.ac.uk/publication.html

Publications

Engineering Archeal Surrogate Systems for the Development of Protein–Protein Interaction Inhibitors against Human RAD51
T Moschetti, T Sharpe, G Fischer, ME Marsh, HK Ng, M Morgan, DE Scott, TL Blundell, A R Venkitaraman, J Skidmore, C Abell, M Hyvönen
– Journal of molecular biology
(2016)
428,
4589
Fragment-based approaches to TB drugs
C Marchetti, DSH Chan, AG Coyne, C Abell
– Parasitology
(2016)
1
Disrupting the Constitutive, Homodimeric Protein-Protein Interface in CK2β Using a Biophysical Fragment-Based Approach.
W-G Seetoh, C Abell
– Journal of the American Chemical Society
(2016)
138,
14303
Label-Free Analysis and Sorting of Microalgae and Cyanobacteria in Microdroplets by Intrinsic Chlorophyll Fluorescence for the Identification of Fast Growing Strains.
RJ Best, JJ Lyczakowski, S Abalde-Cela, Z Yu, C Abell, AG Smith
– Anal Chem
(2016)
88,
10445
Dual-responsive supramolecular colloidal microcapsules from cucurbit[8]uril molecular recognition in microfluidic droplets
Z Yu, Y Lan, RM Parker, W Zhang, X Deng, OA Scherman, C Abell
– Polymer Chemistry
(2016)
7,
5996
Microcapsule Buckling Triggered by Compression-Induced Interfacial Phase Change
AR Salmon, RM Parker, AS Groombridge, A Maestro, RJ Coulston, J Hegemann, J Kierfeld, OA Scherman, C Abell
– Langmuir
(2016)
32,
10987
Hierarchical Self-Assembly of Cellulose Nanocrystals in a Confined Geometry.
RM Parker, B Frka-Petesic, G Guidetti, G Kamita, G Consani, C Abell, S Vignolini
– ACS Nano
(2016)
10,
8443
Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.
ME Kavanagh, JL Gray, SH Gilbert, AG Coyne, KJ McLean, HJ Davis, AW Munro, C Abell
– ChemMedChem
(2016)
11,
1924
Inhibition of Ral GTPases Using a Stapled Peptide Approach.
JC Thomas, JM Cooper, NS Clayton, C Wang, MA White, C Abell, D Owen, HR Mott
– J Biol Chem
(2016)
291,
jbc.M116.720243
Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site
M Kasbekar, G Fischer, BT Mott, A Yasgar, M Hyvönen, HIM Boshoff, C Abell, CE Barry, CJ Thomas
– Proceedings of the National Academy of Sciences of the United States of America
(2016)
113,
7503
  •  
  • 1 of 31
  • >

Research Group

Research Interest Group

Telephone number

01223 336405

Email address

ca26@cam.ac.uk