Yusuf Hamied Department of Chemistry

Publications by Professor Sir David Klenerman FMedSci FRS

Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease.
S De, D Klenerman
Biochimica Et Biophysica Acta Proteins and Proteomics
(2019)
1867
(doi: 10.1016/j.bbapap.2018.12.010)
Imaging rRNA Methylation in Bacteria by MR-FISH
KA Ganzinger, MR Challand, J Spencer, D Klenerman, RT Ranasinghe
Methods Mol Biol
(2019)
2038
(doi: 10.1007/978-1-4939-9674-2_7)
Oligomer Diversity during the Aggregation of the Repeat Region of Tau
M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman
ACS Chemical Neuroscience
(2018)
9
(doi: 10.1021/acschemneuro.8b00250)
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale.
J-E Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, MN Bongiovanni, P Flagmeier, CM Dobson, DJ Wales, SF Lee, D Klenerman
Nano letters
(2018)
18
(doi: 10.1021/acs.nanolett.8b02916)
Quantifying Co-Oligomer Formation by α‑Synuclein
M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, TCT Michaels, D Frenkel, CM Dobson, TPJ Knowles, D Klenerman
ACS Nano
(2018)
12
(doi: 10.1021/acsnano.8b03575)
Filamentous aggregates are fragmented by the proteasome holoenzyme
R Cliffe, JC Sang, F Kundel, D Finley, D Klenerman, Y Ye
Cell Reports
(2018)
(doi: 10.1101/467068)
Sensitive light-sheet microscopy in multiwell plates using an AFM cantilever
A Ponjavic, Y Ye, E Laue, SF Lee, D Klenerman
Biomed Opt Express
(2018)
9
(doi: 10.1364/BOE.9.005863)
Characterisation of particle-surface interactions via anharmonic acoustic transduction
C da Silva Granja, N Sandström, I Efimov, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh
Sensors and Actuators B: Chemical
(2018)
272
(doi: 10.1016/j.snb.2018.05.016)
Correction to: Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman
Acta Neuropathol
(2018)
137
(doi: 10.1007/s00401-018-1919-7)
Direct Observation of Murine Prion Protein Replication in Vitro
JC Sang, G Meisl, AM Thackray, L Hong, A Ponjavic, TPJ Knowles, R Bujdoso, D Klenerman
J Am Chem Soc
(2018)
140
(doi: 10.1021/jacs.8b08311)
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.
DR Whiten, Y Zuo, L Calo, M-L Choi, S De, P Flagmeier, DC Wirthensohn, F Kundel, RT Ranasinghe, SE Sanchez, D Athauda, SF Lee, CM Dobson, S Gandhi, M-G Spillantini, D Klenerman, MH Horrocks
ChemBioChem
(2018)
19
(doi: 10.1002/cbic.201800209)
Cover Feature: Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells (ChemBioChem 19/2018)
DR Whiten, Y Zuo, L Calo, M Choi, S De, P Flagmeier, DC Wirthensohn, F Kundel, RT Ranasinghe, SE Sanchez, D Athauda, SF Lee, CM Dobson, S Gandhi, M Spillantini, D Klenerman, MH Horrocks
ChemBioChem
(2018)
19
(doi: 10.1002/cbic.201800547)
Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution
D Klenerman
Anal Chem
(2018)
90
(doi: 10.1021/acs.analchem.8b02226)
FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells
S Basu, L-M Needham, D Lando, EJR Taylor, KJ Wohlfahrt, D Shah, W Boucher, YL Tan, LE Bates, O Tkachenko, J Cramard, BC Lagerholm, C Eggeling, B Hendrich, D Klenerman, SF Lee, ED Laue
Nature communications
(2018)
9
(doi: 10.1038/s41467-018-04486-0)
Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers.
DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, JR Kumita, H Ecroyd, CM Dobson, D Klenerman, MR Wilson
Cell reports
(2018)
23
(doi: 10.1016/j.celrep.2018.05.074)
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
MHR Ludtmann, PR Angelova, MH Horrocks, ML Choi, M Rodrigues, AY Baev, AV Berezhnov, Z Yao, D Little, B Banushi, AS Al-Menhali, RT Ranasinghe, DR Whiten, R Yapom, KS Dolt, MJ Devine, P Gissen, T Kunath, M Jaganjac, EV Pavlov, D Klenerman, AY Abramov, S Gandhi
Nature Communications
(2018)
9
(doi: 10.1038/s41467-018-04422-2)
Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation
PR Angelova, M-L Choi, MH Horrocks, D Klenerman, S Gandhi, AY Abramov
Free Radical Biology and Medicine
(2018)
120
(doi: 10.1016/j.freeradbiomed.2018.04.137)
Single-Molecule Light-Sheet Imaging of Suspended T Cells.
A Ponjavic, J McColl, AR Carr, AM Santos, K Kulenkampff, A Lippert, SJ Davis, D Klenerman, SF Lee
Biophysical journal
(2018)
114
(doi: 10.1016/j.bpj.2018.02.044)
Weighing one protein with light.
SF Lee, D Klenerman
Science (New York, N.Y.)
(2018)
360
(doi: 10.1126/science.aat5851)
Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell
D Lando, S Basu, TJ Stevens, A Riddell, KJ Wohlfahrt, Y Cao, W Boucher, M Leeb, LP Atkinson, SF Lee, B Hendrich, D Klenerman, ED Laue
Nat Protoc
(2018)
13
(doi: 10.1038/nprot.2018.017)
Yusuf Hamied Department of Chemistry
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