Yusuf Hamied Department of Chemistry

Publications by Professor Sir David Klenerman FMedSci FRS

Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death
C Hughes, ML Choi, J-H Yi, S-C Kim, A Drews, PS George-Hyslop, C Bryant, S Gandhi, K Cho, D Klenerman
Communications biology
(2020)
3
(doi: 10.1038/s42003-020-0792-9)
Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.
JB Sanderson, S De, H Jiang, M Rovere, M Jin, L Zaccagnini, A Hays Watson, L De Boni, VN Lagomarsino, TL Young-Pearse, X Liu, TC Pochapsky, BT Hyman, DW Dickson, D Klenerman, DJ Selkoe, T Bartels
Brain Commun
(2020)
2
(doi: 10.1093/braincomms/fcaa010)
MyD88 death domain oligomerisation determines Myddosome architecture: Implications for TLR signalling
MC Moncrieffe, D Bollschweiler, B Li, PA Penczek, L Hopkins, CE Bryant, D Klenerman, NJ Gay
Structure (London, England : 1993)
(2020)
28
(doi: 10.1016/j.str.2020.01.003)
The costs of close contacts: Visualizing the energy landscape of cell contacts at the nanoscale
K Kulenkampff, AH Lippert, J McColl, AM Santos, A Ponjavic, E Jenkins, J Humphrey, A Winkel, K Franze, SF Lee, SJ Davis, D Klenerman
Biophysical journal
(2020)
118
(doi: 10.1016/j.bpj.2020.01.019)
A General in Vitro Assay for Studying Enzymatic Activities of the Ubiquitin System.
Y Zuo, BK Chong, K Jiang, D Finley, D Klenerman, Y Ye
Biochemistry
(2020)
59
(doi: 10.1021/acs.biochem.9b00602)
High-resolution label-free 3D mapping of extracellular pH of single living cells
Y Zhang, Y Takahashi, SP Hong, F Liu, J Bednarska, PS Goff, P Novak, A Shevchuk, S Gopal, I Barozzi, L Magnani, H Sakai, Y Suguru, T Fujii, A Erofeev, P Gorelkin, A Majouga, DJ Weiss, C Edwards, AP Ivanov, D Klenerman, EV Sviderskaya, JB Edel, Y Korchev
Nature Communications
(2019)
10
(doi: 10.1038/s41467-019-13535-1)
α-Synuclein strains target distinct brain regions and cell types.
A Lau, RWL So, HHC Lau, JC Sang, A Ruiz-Riquelme, SC Fleck, E Stuart, S Menon, NP Visanji, G Meisl, R Faidi, MM Marano, C Schmitt-Ulms, Z Wang, PE Fraser, A Tandon, BT Hyman, H Wille, M Ingelsson, D Klenerman, JC Watts
Nature neuroscience
(2019)
23
(doi: 10.1038/s41593-019-0541-x)
N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme
Y Ye, D Klenerman, D Finley
J Mol Biol
(2019)
432
(doi: 10.1016/j.jmb.2019.08.021)
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman
Acta neuropathologica communications
(2019)
7
(doi: 10.1186/s40478-019-0777-4)
A cell topography-based mechanism for ligand discrimination by the T cell receptor.
RA Fernandes, KA Ganzinger, JC Tzou, P Jönsson, SF Lee, M Palayret, AM Santos, AR Carr, A Ponjavic, VT Chang, C Macleod, BC Lagerholm, AE Lindsay, O Dushek, A Tilevik, SJ Davis, D Klenerman
Proc Natl Acad Sci U S A
(2019)
116
(doi: 10.1073/pnas.1817255116)
A general in vitro assay to study enzymatic activities of the ubiquitin system
Y Zuo, BK Chong, K Jiang, D Finley, D Klenerman, Y Ye
(2019)
(doi: 10.1101/660894)
Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates
T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, SIA Cohen, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles, P Arosio
Science Advances
(2019)
5
(doi: 10.1126/sciadv.aau3112)
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
Nature Communications
(2019)
10
(doi: 10.1038/s41467-019-09477-3)
Citrullination of HP1γ chromodomain affects association with chromatin.
M Wiese, AJ Bannister, S Basu, W Boucher, K Wohlfahrt, MA Christophorou, ML Nielsen, D Klenerman, ED Laue, T Kouzarides
Epigenetics & chromatin
(2019)
12
(doi: 10.1186/s13072-019-0265-x)
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species.
JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman
Chemical Science
(2019)
10
(doi: 10.1039/c8sc05627g)
Spectrally-Resolved Photodynamics Of Individual Emitters In Large-Area Monolayers Of Hexagonal-Boron Nitride.
HL Stern, R Wang, Y Fan, R Mizuta, JC Stewart, L-M Needham, TD Roberts, R Wai, NS Ginsberg, D Klenerman, S Hofmann, SF Lee
ACS Nano
(2019)
13
(doi: 10.1021/acsnano.9b00274)
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse
ACS chemical neuroscience
(2019)
10
(doi: 10.1021/acschemneuro.8b00676)
Filamentous aggregates are fragmented by the proteasome holoenzyme
R Cliffe, JC Sang, F Kundel, D Finley, D Klenerman, Y Ye
Cell reports
(2019)
26
(doi: 10.1016/j.celrep.2019.01.096)
Simple and ultrafast resonance frequency and dissipation shift measurements using a fixed frequency drive
A Guha, N Sandström, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh
Sensors and Actuators B Chemical
(2019)
281
(doi: 10.1016/j.snb.2018.11.052)
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.
CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman
Acta Neuropathol
(2019)
137
(doi: 10.1007/s00401-018-1907-y)
Yusuf Hamied Department of Chemistry
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