Yusuf Hamied Department of Chemistry

Publications by Professor Sir David Klenerman FMedSci FRS

Construction of a liquid-liquid phase separation system from the gel-sol transition of elongated protein microgels in a crowding agent
Y Xu, R Qi, H Zhu, B Li, Y Shen, G Krainer, D Klenerman, TPJ Knowles
(2020)
(doi: 10.1101/2020.12.08.416867)
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer’s R47H mutant does the opposite
A Vilalta, Y Zhou, J Sevalle, JK Griffin, K Satoh, DH Allendorf, S De, M Puigdellívol, A Bruzas, MA Burguillos, RB Dodd, F Chen, Y Zhang, P Flagmeier, L-M Needham, M Enomoto, S Qamar, J Henderson, J Walter, PE Fraser, D Klenerman, SF Lee, P St George-Hyslop, GC Brown
(2020)
(doi: 10.1101/2020.12.03.409995)
Soft Polydimethylsiloxane-Supported Lipid Bilayers for Studying T Cell Interactions
AH Lippert, IB Dimov, AK Winkel, J Humphrey, J McColl, KY Chen, AM Santos, E Jenkins, K Franze, SJ Davis, D Klenerman
Biophysical journal
(2020)
120
(doi: 10.1016/j.bpj.2020.11.021)
Amyloid precipitation in biofluids using a structure-specific chemical antibody
M Rodrigues, P Bhattacharjee, A Brinkmalm, D Do, C Pearson, S De, A Ponjavic, J Varela, F Ruggeri, I Baudrexel, J Lee, A Carr, K Kulenkampff, T Knowles, H Zetterberg, T Snaddon, S Gandhi, S Lee, D Klenerman
(2020)
(doi: 10.21203/rs.3.rs-81521/v1)
Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation.
PR Angelova, ML Choi, AV Berezhnov, MH Horrocks, CD Hughes, S De, M Rodrigues, R Yapom, D Little, KS Dolt, T Kunath, MJ Devine, P Gissen, MS Shchepinov, S Sylantyev, EV Pavlov, D Klenerman, AY Abramov, S Gandhi
Cell Death & Differentiation
(2020)
28
(doi: 10.1038/s41418-020-00634-6)
Developing Therapies for Neurodegenerative Disorders: Insights from Protein Aggregation and Cellular Stress Responses
GR Mallucci, D Klenerman, DC Rubinsztein
Annual review of cell and developmental biology
(2020)
36
(doi: 10.1146/annurev-cellbio-040320-120625)
Tumour necrosis factor induces increased production of extracellular amyloid-β-and α-synuclein-containing aggregates by human Alzheimer's disease neurons
DR Whiten, PW Brownjohn, S Moore, S De, A Strano, Y Zuo, M Haneklaus, D Klenerman, FJ Livesey
Brain communication
(2020)
2
(doi: 10.1093/braincomms/fcaa146)
Direct measurement of lipid membrane disruption connects kinetics and toxicity of A beta 42 aggregation
P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, M Vendruscolo, S Linse, D Klenerman, TPJ Knowles, CM Dobson
Nature Structural and Molecular Biology
(2020)
27
(doi: 10.1038/s41594-020-0471-z)
Direct detection of whole bacteria using a nonlinear acoustic resonator
S Khobragade, C Da Silva Granja, N Sandström, I Efimov, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh
Sensors and Actuators B: Chemical
(2020)
316
(doi: 10.1016/j.snb.2020.128086)
Single-molecule visualization of DNA G-quadruplex formation in live cells
M Di Antonio, A Ponjavic, A Radzevičius, RT Ranasinghe, M Catalano, X Zhang, J Shen, L-M Needham, SF Lee, D Klenerman, S Balasubramanian
Nature Chemistry
(2020)
12
(doi: 10.1038/s41557-020-0506-4)
Direct digital sensing of protein biomarkers in solution
G Krainer, KL Saar, WE Arter, TJ Welsh, MA Czekalska, RPB Jacquat, Q Peter, WC Traberg, A Pujari, AK Jayaram, P Challa, CG Taylor, L-M van der Linden, T Franzmann, RM Owens, S Alberti, D Klenerman, TPJ Knowles
BIOPHYSICAL JOURNAL
(2020)
120
(doi: 10.1101/2020.05.24.113498)
Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit.
WE Arter, Y Yusim, Q Peter, CG Taylor, D Klenerman, UF Keyser, TPJ Knowles
ACS Nano
(2020)
14
(doi: 10.1021/acsnano.0c00628)
Kinetic diversity of amyloid oligomers.
AJ Dear, TCT Michaels, G Meisl, D Klenerman, S Wu, S Perrett, S Linse, CM Dobson, TPJ Knowles
Proceedings of the National Academy of Sciences
(2020)
117
(doi: 10.1073/pnas.1922267117)
Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation.
PR Angelova, ML Choi, AV Berezhnov, MH Horrocks, CD Hughes, S De, M Rodrigues, R Yapom, D Little, KS Dolt, T Kunath, MJ Devine, P Gissen, MS Shchepinov, S Sylantyev, EV Pavlov, D Klenerman, AY Abramov, S Gandhi
Cell Death Differ
(2020)
27
(doi: 10.1038/s41418-020-0552-x)
ThX - a next-generation probe for the early detection of amyloid aggregates.
L-M Needham, J Weber, JA Varela, JWB Fyfe, DT Do, CK Xu, L Tutton, R Cliffe, B Keenlyside, D Klenerman, CM Dobson, CA Hunter, KH Müller, K O'Holleran, SE Bohndiek, TN Snaddon, SF Lee
Chemical Science
(2020)
11
(doi: 10.1039/c9sc04730a)
Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage-gated calcium channels and NADPH oxidase
N Esteras, F Kundel, GF Amodeo, EV Pavlov, D Klenerman, AY Abramov
The FEBS Journal
(2020)
288
(doi: 10.1111/febs.15340)
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation.
PR Angelova, ML Choi, AV Berezhnov, MH Horrocks, CD Hughes, S De, M Rodrigues, R Yapom, D Little, KS Dolt, T Kunath, MJ Devine, P Gissen, MS Shchepinov, S Sylantyev, EV Pavlov, D Klenerman, AY Abramov, S Gandhi
Cell Death & Differentiation
(2020)
27
(doi: 10.1038/s41418-020-0542-z)
A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein
Y Zhao, O Tietz, W-L Kuan, AK Haji-Dheere, S Thompson, B Vallin, E Ronchi, G Tóth, D Klenerman, FI Aigbirhio
Chemical Science
(2020)
11
(doi: 10.1039/c9sc05620c)
Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics
S Basu, O Shukron, D Hall, P Parutto, A Ponjavic, D Shah, W Boucher, D Lando, W Zhang, N Reynolds, L Sober, A Jartseva, R Ragheb, X Ma, J Cramard, R Floyd, G Brown, J Balmer, T Drury, A Carr, L-M Needham, A Aubert, G Communie, K Gor, M Steindel, L Morey, E Blanco, T Bartke, L Di Croce, I Berger, C Schaffitzel, S Lee, T Stevens, D Klenerman, B Hendrich, D Holcman, E Laue
BioRxiv
(2020)
(doi: 10.1101/2020.04.03.003178)
The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.
G Meisl, TP Knowles, D Klenerman
Current Opinion in Neurobiology
(2020)
61
(doi: 10.1016/j.conb.2020.01.010)
Yusuf Hamied Department of Chemistry
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