Yusuf Hamied Department of Chemistry

Publications by Professor Sir David Klenerman FMedSci FRS

The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide
B Li, P Suresh, J Brelstaff, S Kedia, CE Bryant, D Klenerman
(2024)
(doi: 10.7554/eLife.92350)
The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide
B Li, P Suresh, J Brelstaff, S Kedia, CE Bryant, D Klenerman
eLife
(2024)
13
(doi: 10.7554/elife.92350.3)
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease.
Z Xia, EE Prescott, A Urbanek, HE Wareing, MC King, A Olerinyova, H Dakin, T Leah, KA Barnes, MM Matuszyk, E Dimou, E Hidari, YP Zhang, JYL Lam, JSH Danial, MR Strickland, H Jiang, P Thornton, DC Crowther, S Ohtonen, M Gómez-Budia, SM Bell, L Ferraiuolo, H Mortiboys, A Higginbottom, SB Wharton, DM Holtzman, T Malm, RT Ranasinghe, D Klenerman, S De
Nature communications
(2024)
15
(doi: 10.1038/s41467-024-49028-z)
Single-molecule characterization of salivary protein aggregates from Parkinson’s disease patients: a pilot study
M Furlepa, YP Zhang, E Lobanova, L Kahanawita, G Vivacqua, CH Williams-Gray, D Klenerman
Brain Communications
(2024)
6
(doi: 10.1093/braincomms/fcae178)
The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS
B Li, P Suresh, J Brelstaff, S Kedia, C Bryant, D Klenerman
(2024)
(doi: 10.7554/elife.92350.2)
Single‐Molecule Characterization and Super‐Resolution Imaging of Alzheimer's Disease‐Relevant Tau Aggregates in Human Samples
D Böken, D Cox, M Burke, JYL Lam, T Katsinelos, JSH Danial, E Fertan, WA McEwan, JB Rowe, D Klenerman
Angewandte Chemie International Edition
(2024)
136
(doi: 10.1002/ange.202317756)
Single‐Molecule Characterization and Super‐Resolution Imaging of Alzheimer's Disease‐Relevant Tau Aggregates in Human Samples
D Böken, D Cox, M Burke, JYL Lam, T Katsinelos, JSH Danial, E Fertan, WA McEwan, JB Rowe, D Klenerman
Angewandte Chemie International Edition
(2024)
63
(doi: 10.1002/anie.202317756)
APP antisense oligonucleotides reduce amyloid-β aggregation and rescue endolysosomal dysfunction in Alzheimer's disease
C Hung, E Fertan, FJ Livesey, D Klenerman, R Patani
Brain
(2024)
147
(doi: 10.1093/brain/awae092)
High-density volumetric super-resolution microscopy
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O’Holleran, SF Lee
Nature Communications
(2024)
15
(doi: 10.1038/s41467-024-45828-5)
Astrocytic RNA editing regulates the host immune response to alpha-synuclein
K D’Sa, ML Choi, AZ Wagen, N Setó-Salvia, O Kopach, JR Evans, M Rodrigues, P Lopez-Garcia, J Lachica, J Singh, A Ghareeb, J Bayne, M Grant-Peters, S Garcia-Ruiz, Z Chen, S Rodriques, D Athauda, E Gustavsson, SAG Taliun, C Toomey, RH Reynolds, G Young, S Strohbuecker, T Warner, DA Rusakov, R Patani, C Bryant, DA Klenerman, S Gandhi, M Ryten
(2024)
(doi: 10.1101/2024.02.26.582055)
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases
AH Lippert, C Paluch, M Gaglioni, MT Vuong, J McColl, E Jenkins, M Fellermeyer, J Clarke, S Sharma, S Moreira da Silva, B Akkaya, C Anzilotti, SH Morgan, CF Jessup, M Körbel, U Gileadi, J Leitner, R Knox, M Chirifu, J Huo, S Yu, N Ashman, Y Lui, I Wilkinson, KE Attfield, L Fugger, NJ Robertson, CJ Lynch, L Murray, P Steinberger, AM Santos, SF Lee, RJ Cornall, D Klenerman, SJ Davis
Immunity
(2024)
57
(doi: 10.1016/j.immuni.2024.01.007)
Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
S Basu, O Shukron, D Hall, P Parutto, A Ponjavic, D Shah, W Boucher, D Lando, W Zhang, N Reynolds, LH Sober, A Jartseva, R Ragheb, X Ma, J Cramard, R Floyd, J Balmer, TA Drury, AR Carr, L-M Needham, A Aubert, G Communie, K Gor, M Steindel, L Morey, E Blanco, T Bartke, L Di Croce, I Berger, C Schaffitzel, SF Lee, TJ Stevens, D Klenerman, BD Hendrich, D Holcman, ED Laue
Nature structural & molecular biology
(2023)
31
(doi: 10.1038/s41594-023-01179-1)
Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy.
E Fertan, D Böken, A Murray, JSH Danial, JYL Lam, Y Wu, PA Goh, I Alić, MR Cheetham, E Lobanova, YP Zhang, D Nižetić, D Klenerman
Molecular psychiatry
(2023)
29
(doi: 10.1038/s41380-023-02333-3)
Imaging protein aggregates in Parkinson’s disease serum using aptamer-assisted single-molecule pull-down
YP Zhang, E Lobanova, D Emin, SV Lobanov, A Kouli, CH Williams-Gray, D Klenerman
Analytical Chemistry
(2023)
95
(doi: 10.1021/acs.analchem.3c02515)
The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS
B Li, P Suresh, J Brelstaff, S Kedia, C Bryant, D Klenerman
(2023)
(doi: 10.1101/2023.09.28.559977)
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD
S Basu, O Shukron, D Hall, P Parutto, A Ponjavic, D Shah, W Boucher, D Lando, W Zhang, N Reynolds, LH Sober, A Jartseva, R Ragheb, X Ma, J Cramard, R Floyd, J Balmer, TA Drury, AR Carr, L-M Needham, A Aubert, G Communie, K Gor, M Steindel, L Morey, E Blanco, T Bartke, L Di Croce, I Berger, C Schaffitzel, SF Lee, TJ Stevens, D Klenerman, BD Hendrich, D Holcman, ED Laue
Nature Structural & Molecular Biology
(2023)
30
(doi: 10.1038/s41594-023-01095-4)
Author Correction: Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging.
JSH Danial, JYL Lam, Y Wu, M Woolley, E Dimou, MR Cheetham, D Emin, D Klenerman
Nature protocols
(2023)
18
(doi: 10.1038/s41596-023-00909-5)
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
E Dimou, T Katsinelos, G Meisl, BJ Tuck, S Keeling, AE Smith, E Hidari, JYL Lam, M Burke, S Lövestam, RT Ranasinghe, WA McEwan, D Klenerman
Cell reports
(2023)
42
(doi: 10.1016/j.celrep.2023.112725)
A Computational Suite for the Structural and Functional Characterisation of Amyloid Aggregates
Z Xia, Y Wu, JYL Lam, Z Zhang, M Burke, E Fertan, RT Ranasinghe, E Hidari, JSH Danial, D Klenerman
Cell reports methods
(2023)
3
(doi: 10.1016/j.crmeth.2023.100499)
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains.
A Miller, J Wei, S Meehan, CM Dobson, ME Welland, D Klenerman, M Vendruscolo, FS Ruggeri, TPJ Knowles
Proc Natl Acad Sci U S A
(2023)
120
(doi: 10.1073/pnas.2216234120)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

Privacy and cookie policy

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge