Yusuf Hamied Department of Chemistry

Publications by Professor Sir David Klenerman FMedSci FRS

A non-catalytic role for MLL2 in controlling chromatin organisation and mobility during the priming of pluripotent cells for differentiation
M Steindel, O Davis, K Neumann, G Agsu, L Mao, A Kranz, L Pirvan, D Adhya, J Morf, Z Zhang, S Yang, J Fu, M Barile, A Wurmser, SE Strawbridge, N Chalabyan, P Madapura, B Huntly, B Göttgens, D Holcman, SA Samarajiwa, D Klenerman, K Anastassiadis, AF Stewart, S Basu
(2025)
(doi: 10.1101/2025.02.21.639010)
Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform (vol 97, pg 290, 2025)
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
Anal Chem
(2025)
97
(doi: 10.1021/acs.analchem.5c00703)
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy.
S Kedia, E Fertan, Y Wu, YP Zhang, G Meisl, JYL Lam, F K Wiseman, WA McEwan, A Quaegebeur, MG Spillantini, JSH Danial, D Klenerman
Cell Chemical Biology
(2025)
32
(doi: 10.1016/j.chembiol.2025.01.001)
Detecting the Undetectable: Advances in Methods for Identifying Small Tau Aggregates in Neurodegenerative Diseases.
D Böken, Y Wu, Z Zhang, D Klenerman
Chembiochem
(2025)
26
(doi: 10.1002/cbic.202400877)
Detecting alpha-synuclein aggregates with small molecules on single-molecule array
JYL Lam, TS Chisholm, H Almahli, EA English, Z Xia, Y Wu, MR Cheetham, CA Hunter, D Klenerman
Chemical Science
(2025)
16
(doi: 10.1039/d4sc07649d)
Ultra-sensitive protein aggregate quantification assays for neurodegenerative diseases on the Simoa platform
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
Anal Chem
(2024)
97
(doi: 10.1021/acs.analchem.4c04188)
Tau accumulation patterns in PSP constrain mechanisms and quantify cell-to-cell and cell-autonomous aggregation rates
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TP Knowles, JB Rowe, D Klenerman, G Meisl
(2024)
(doi: 10.1101/2024.12.14.24318991)
Clearance of beta-amyloid and tau aggregates is size dependent and altered by an inflammatory challenge
E Fertan, C Hung, JSH Danial, JYL Lam, P Preman, G Albertini, EA English, D Böken, FJ Livesey, B De Strooper, R Patani, D Klenerman
Brain Communications
(2024)
7
(doi: 10.1093/braincomms/fcae454)
ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases.
D Klenerman
Nature Communications
(2024)
15
(doi: 10.1038/s41467-024-53547-0)
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
P Preman, D Moechars, E Fertan, L Wolfs, L Serneels, D Shah, J Lamote, S Poovathingal, A Snellinx, R Mancuso, S Balusu, D Klenerman, AM Arranz, M Fiers, B De Strooper
EMBO molecular medicine
(2024)
16
(doi: 10.1038/s44321-024-00162-7)
Single-molecule characterisation of soluble beta-amyloid aggregate binding by Aducanumab, Lecanemab, Gantenerumab, and Donanemab
D Klenerman, E Fertan, J Lam, G Albertini, M Dewilde, Y Wu, O Akingbade, D Böken, E English, B De Strooper
(2024)
(doi: 10.21203/rs.3.rs-5290983/v1)
Single-molecule characterisation of soluble beta-amyloid aggregate binding by Aducanumab, Lecanemab, Gantenerumab, and Donanemab
E Fertan, JYL Lam, G Albertini, M Dewilde, Y Wu, OES Akingbade, D Böken, EA English, B De Strooper, D Klenerman
(2024)
(doi: 10.1101/2024.10.11.617910)
POLCAM: instant molecular orientation microscopy for the life sciences
E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, AS Klymchenko, SJ Davis, EK Paluch, D Klenerman, MD Lew, K O'Holleran, SF Lee
Nature methods
(2024)
21
(doi: 10.1038/s41592-024-02382-8)
A human neuronal model of sporadic Alzheimer’s disease induced byFBXO2downregulation shows Aβ aggregation, tau hyperphosphorylation and functional network impairment
AG Díaz, A Possenti, GA Urrutia, Y Bian, S Kedia, D Boeken, CM Lim, D Licastro, B Mannini, D Klenerman, M Vendruscolo
(2024)
(doi: 10.1101/2024.09.01.610673)
Hyaluronidase unlocks sequestered CEACAM5 and improves CAR T-cell therapy in colorectal cancer
D Banik, C Ward, Z Zhang, S Chakraborty, D Heraghty, P Suresh, B Li, S Kedia, SJ Davis, JP Roy, MA Chapman, B Mahata, D Klenerman
(2024)
(doi: 10.1101/2024.08.29.610222)
Aggregate-selective removal of pathological tau by clustering-activated degraders
J Benn, S Cheng, S Keeling, AE Smith, MJ Vaysburd, D Böken, LVC Miller, T Katsinelos, C Franco, E Dupré, C Danis, I Landrieu, L Buée, D Klenerman, LC James, WA McEwan
Science
(2024)
385
(doi: 10.1126/science.adp5186)
SynPull: a novel method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy
S Kedia, E Fertan, Y Wu, YP Zhang, G Meisl, JYL Lam, F Wiseman, WA McEwan, A Quaegebeur, MG Spillantini, JSH Danial, D Klenerman
(2024)
(doi: 10.1101/2024.08.24.609517)
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
RM Rajani, R Ellingford, M Hellmuth, SS Harris, OS Taso, D Graykowski, FKW Lam, C Arber, E Fertan, JSH Danial, M Swire, M Lloyd, TA Giovannucci, M Bourdenx, D Klenerman, R Vassar, S Wray, C Sala Frigerio, MA Busche
PLOS Biology
(2024)
22
(doi: 10.1371/journal.pbio.3002727)
Improved Imaging Surface for Quantitative Single-Molecule Microscopy.
YP Zhang, E Lobanova, A Dworkin, M Furlepa, WS Yang, M Burke, JX Meng, N Potter, RL Sala, L Kahanawita, F Layburn, OA Scherman, CH Williams-Gray, D Klenerman
ACS Applied Materials and Interfaces
(2024)
16
(doi: 10.1021/acsami.4c06512)
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s Disease
RM Rajani, R Ellingford, M Hellmuth, SS Harris, OS Taso, D Graykowski, FKW Lam, C Arber, E Fertan, JSH Danial, M Swire, M Lloyd, TA Giovannucci, M Bourdenx, D Klenerman, R Vassar, S Wray, CS Frigerio, MA Busche
(2024)
(doi: 10.1101/2024.06.21.600003)
Yusuf Hamied Department of Chemistry
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