Yusuf Hamied Department of Chemistry

Publications by Professor Sir David Klenerman FMedSci FRS

Beyond prion-like spreading in neurodegenerative disease.
G Meisl, JB Rowe, D Klenerman
Alzheimer's & Dementia
(2025)
21
(doi: 10.1002/alz.70789)
Beyond prion‐like spreading in neurodegenerative disease
G Meisl, JB Rowe, D Klenerman
(2025)
21
Single-Oligomer Characterization of Tau Phosphorylation and Mechanical State.
VVS Pillai, T Smeding, JX Meng, D Klenerman, FS Ruggeri
ACS measurement science au
(2025)
5
(doi: 10.1021/acsmeasuresciau.5c00116)
Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation.
N Quittot, D Sivasankaran, D Boeken, Y Chen, JE Chun, A Wiedmer, V Derosla, MBMS Martins, FA Brooks, G Meisl, M Cotton, DG Arumuganainar, T Connors, A Melloni, M Frosch, D Oakley, L Makowski, M Wanunu, D Klenerman, BT Hyman
bioRxiv
(2025)
(doi: 10.1101/2025.09.24.678227)
Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP-43-Positive Assemblies in Motor Neuron Disease.
D Cox, M Burke, S Milani, MA White, FM Waldron, D Böken, E Lobanova, J Sreedharan, JM Gregory, D Klenerman
Advanced Science
(2025)
12
(doi: 10.1002/advs.202505484)
Super-resolution microscopy of nanoscopic alpha-synuclein aggregates in brain samples indicates a subset of cells have disrupted protein homeostasis prior to Lewy body formation in Parkinson’s disease
E Fertan, JSH Danial, S Neame, JYL Lam, MW Cotton, M Burke, Z Xia, Y Wu, B Powney, Y Imaizumi, A Quaegebeur, G Meisl, J Staddon, D Klenerman
(2025)
(doi: 10.1101/2025.09.16.676632)
Early synaptic pathology is associated with small tau aggregates in Alzheimer’s disease
E Fertan, S Kedia, G Meisl, MW Cotton, A Quaegebeur, MG Spillantini, D Klenerman
(2025)
(doi: 10.1101/2025.09.13.676039)
T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts
M Kotowski, DF Heraghty, M Körbel, D Banik, Z Zhang, S Kedia, B Fu, J McColl, B Li, J Clarke, M Fellermeyer, Y Lui, G Bossi, DK Cole, H Chen, E Basiarz, S Sharma, E Petsalaki, CJ Tape, B de Wet, SF Lee, AM Santos, D Klenerman, SJ Davis
(2025)
(doi: 10.1101/2025.08.29.673015)
Nanoscopic tau aggregates in Parkinson’s disease
F Layburn, D Boeken, YP Zhang, K Halliday, D Rodgers, L Kahanawita, B Patel, A Quaegebeur, CH Williams-Gray, D Klenerman
(2025)
(doi: 10.1101/2025.08.28.672923)
HP1β and densely packed chromatin form separate microdomains in mouse ES cells, which are reconfigured upon exit from naïve pluripotency
A Ochirova, D Shah, Z Zhang, A Ponjavic, K Uzwyshyn-Jones, D Lando, M Wiese, X Ma, N Reynolds, A Koulle, W Boucher, MO Lenz, BD Hendrich, D Klenerman, ED Laue
(2025)
(doi: 10.1101/2025.08.25.671447)
DHPSFU: a Fiji plugin for fast and accurate double helix-PSF 3D single-molecule localisation microscopy.
Z Zhang, A Ochirova, S Liu, AD Herbert, Y Wu, W Boucher, SF Lee, ED Laue, D Klenerman, A Ponjavic
Scientific reports
(2025)
15
(doi: 10.1038/s41598-025-15623-3)
Small diffusible aggregates, plaques, tangles, and dynamic equilibria: untangling Alzheimer’s disease
E Fertan, G Meisl, D Klenerman
Alzheimer's & Dementia
(2025)
21
(doi: 10.1002/alz.70462)
Small‐diffusible aggregates, plaques, tangles, and dynamic equilibria: Untangling Alzheimer's disease
E Fertan, G Meisl, D Klenerman
(2025)
21
Small tau aggregates exhibit disease-specific molecular profiles across tauopathies
D Böken, M Huang, Y Wu, E Fertan, JYL Lam, G Meisl, S Baig, JB Rowe, C Smith, A Quaegebeur, D Cox, WA McEwan, D Klenerman
(2025)
(doi: 10.1101/2025.06.10.658934)
Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytes
S Goldsworthy, E Fertan, P Dyal, S Domoney, FJ Livesey, D Klenerman, R Patani, C Hung
(2025)
(doi: 10.1101/2025.05.27.656416)
Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency
A Leithner, O Staufer, T Mitra, F Liberta, S Valvo, M Kutuzov, H Dada, J Spaeth, W Zhou, F Schiele, S Reindl, H Nar, S Hoerer, M Crames, S Comeau, D Young, S Low, E Jenkins, SJ Davis, D Klenerman, A Nixon, N Pefaur, D Wyatt, O Dushek, S Kasturirangan, ML Dustin
Proceedings of the National Academy of Sciences of the United States of America
(2025)
122
(doi: 10.1073/pnas.2425781122)
Detection of p53 aggregates in plasma of glioma patients
Y Wu, JYL Lam, M Pitoulias, D Böken, Z Zhang, R Chintapalli, E Fertan, Z Xia, JSH Danial, G Tsang-Pells, E Fysh, L Julian, KM Brindle, R Mair, D Klenerman
Communications Medicine
(2025)
5
(doi: 10.1038/s43856-025-00918-3)
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease
E Fertan, JYL Lam, G Albertini, M Dewilde, Y Wu, OES Akingbade, D Böken, EA English, B De Strooper, D Klenerman
Alzheimer's & Dementia
(2025)
21
(doi: 10.1002/alz.70086)
Astrocytic RNA editing regulates the host immune response to alpha-synuclein.
K D'Sa, ML Choi, AZ Wagen, N Setó-Salvia, O Kopach, JR Evans, M Rodrigues, P Lopez-Garcia, J Lachica, BE Clarke, J Singh, A Ghareeb, J Bayne, M Grant-Peters, S Garcia-Ruiz, Z Chen, S Rodriques, D Athauda, EK Gustavsson, SA Gagliano Taliun, C Toomey, RH Reynolds, G Young, S Strohbuecker, T Warner, DA Rusakov, R Patani, C Bryant, DA Klenerman, S Gandhi, M Ryten
Science Advances
(2025)
11
(doi: 10.1126/sciadv.adp8504)
Fingerprinting disease-derived protein aggregates reveals unique signature of Motor Neuron Disease
D Cox, M Burke, S Milani, MA White, FM Waldron, D Böken, E Lobanova, J Sreedharan, JM Gregory, D Klenerman
(2025)
(doi: 10.1101/2025.03.04.641150)
Yusuf Hamied Department of Chemistry
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