Yusuf Hamied Department of Chemistry

Publications by Professor Sir David Klenerman FMedSci FRS

Single-molecule detection methods to study alpha-synuclein aggregation in postmortem Parkinson's disease brains.
E Fertan, JSH Danial, S Neame, JYL Lam, MW Cotton, M Burke, Z Xia, Y Wu, B Powney, Y Imaizumi, A Quaegebeur, G Meisl, J Staddon, D Klenerman
Cell Rep Methods
(2026)
(doi: 10.1016/j.crmeth.2026.101418)
Spatially patterned, spectral single-molecule microscopy
JS Beckwith, B Cullinane, DF Heraghty, S Krokowski, CL Jones, S Yang, RC Gregory, RA Floto, AM Santos, SJ Davis, M Vendruscolo, D Klenerman, V Lindo, PK Sankaran, SF Lee
(2026)
(doi: 10.64898/2026.04.08.715690)
Cortisol-resistant CAR-NK cells overcome steroid-induced immunosuppression in lung cancer.
S Chakraborty, J Pramanik, G Alviter-Raymundo, CJ Ward, SK Shaji, Y Yamashita-Kanemaru, FAZ Ali, D Banik, Z Zhang, C Veiga-Villauriz, NZM Homer, J Simpson, S Laforest, S Tong, Q Zhao, J Roy, M Iqbal, AC Morris, MA Chapman, R Roychoudhuri, H Hussein, D Klenerman, K Saeb-Parsy, B Mahata
Signal Transduct Target Ther
(2026)
11
(doi: 10.1038/s41392-026-02638-z)
A Correlative SICM-OPM Platform for Surface and Volumetric Imaging in Live Cells
W Hong, Z Zhang, A Li, T Sun, Y Wu, DM Vadukul, D Jones, B Li, F Liu, FA Aprile, Y Korchev, J Gorelik, D Klenerman, A Shevchuk
Advanced Science
(2026)
(doi: 10.1002/advs.75222)
Alzheimer’s disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits
R Ellingford, SS Harris, M Kehring, RM Rajani, FKW Lam, D Graykowski, D Bӧken, LA Welikovitch, A Khasnavis, R Laban, A Heslegrave, U Yaman, A Mate de Gerando, SA Bond, S Wray, DA Salih, D Dupret, RJ Dolan, D Klenerman, H Zetterberg, BT Hyman, MA Busche
Neuron
(2026)
(doi: 10.1016/j.neuron.2026.02.027)
Constructing a single-objective oblique plane microscope (OPM) for fast, multi-colour, high-resolution volumetric fluorescence imaging
Z Zhang, W Hong, Y Wu, A Dey, A Shevchuk, D Klenerman
(2026)
(doi: 10.64898/2026.03.04.709686)
Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome
MC Moncrieffe, P Suresh, J Boyle, Y Cui, B Nawalpuri, B Verstak, YP Zhang, Z Zhang, M Taylor, EH Egelman, N Gay, D Klenerman, C Bryant
Science advances
(2026)
12
(doi: 10.1126/sciadv.aeb9507)
Nanoscopic tau aggregates are not shared intermediates but disease-specific entities across tauopathies.
D Böken, M Huang, Y Wu, E Fertan, MW Cotton, G Meisl, JYL Lam, S Baig, JB Rowe, C Smith, A Quaegebeur, D Cox, WA McEwan, D Klenerman
Cell reports
(2026)
45
(doi: 10.1016/j.celrep.2026.116934)
A universal phase-plane model for in vivo protein aggregation.
MW Cotton, A Goriely, D Klenerman, G Meisl
The Journal of chemical physics
(2026)
164
(doi: 10.1063/5.0312752)
A cell-level model to predict the spatiotemporal dynamics of neurodegenerative disease
S-H Huang, 黃士桓, MW Cotton, TPJ Knowles, D Klenerman, G Meisl
Prx Life
(2026)
4
(doi: 10.1103/f9hz-xvpr)
A cell-level model to predict the spatiotemporal dynamics of neurodegenerative disease
S-H Huang, MW Cotton, TPJ Knowles, D Klenerman, G Meisl
(2026)
(doi: 10.48550/arxiv.2508.15046)
Early synaptic pathology is associated with small tau aggregates in Alzheimer’s disease
E Fertan, S Kedia, G Nolan, G Meisl, MW Cotton, KH Müller, Z Zhang, L Muresan, A Quaegebeur, MG Spillantini, D Klenerman
Acta Neuropathologica
(2026)
151
(doi: 10.1007/s00401-026-02977-9)
Enzymatic Remodelling of Tumour Microenvironment Enhances Anti-CEACAM5 CAR T-Cell Efficacy Against Colorectal Cancer
D Banik, CJ Ward, S Chakraborty, Z Zhang, D Heraghty, P Suresh, B Li, S Kedia, J Pramanik, SJ Davis, JP Roy, MA Chapman, B Mahata, D Klenerman
Advanced Science
(2026)
13
(doi: 10.1002/advs.202509762)
Patch deconvolution for Fourier light-field microscopy
B Fu, CL Jones, D Heraghty, S Yang, C O'Brien-Ball, V Junghans, H Yang, D Klenerman, TPJ Knowles, LE Weiss, RA Fernandes, SF Lee
Biophys J
(2026)
125
(doi: 10.1016/j.bpj.2026.01.034)
Single-molecule imaging of small aggregates of IAPP in type 2 diabetes serum with rationally-designed antibody-like scaffolds
J Lin, YP Zhang, S Chia, D Klenerman, P Sormanni, M Vendruscolo
Chemical Science
(2025)
17
(doi: 10.1039/d5sc01427a)
Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells
GG Agsu, Y Cao, D Jain, SE Strawbridge, S Daly, Z Zhang, A Wurmser, K Bowers, IO De Almeida, G Nikolenyi, S Berger, M Jonaitis, K Guma’a, T Pauzaite, S Maretvadakethope, L Bates, JA Nathan, BD Hendrich, R Perez-Carrasco, KJ Chalut, D Klenerman, TE Boroviak, SF Lee, D Holcman, S Basu
(2025)
(doi: 10.64898/2025.12.03.691924)
Stress-Induced Reorganization of Proteasomes Through Diffusion and Cytoskeleton-Dependent Mechanisms.
MJ Morten, Y Zhang, B Li, JX Meng, K Jiang, L Sirvio, J-E Lee, AH Lippert, M Burridge, KD Pulgar Prieto, AR Carr, A Ponjavic, SF Lee, D Finley, D Klenerman, Y Ye
Small
(2025)
22
(doi: 10.1002/smll.202506260)
Rethinking neurodegeneration through a co-proteinopathy lens
YP Zhang, S Kedia, D Klenerman
Trends in neurosciences
(2025)
48
(doi: 10.1016/j.tins.2025.10.006)
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal.
MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, E Fertan, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl
(2025)
(doi: 10.1101/2025.09.08.674880)
A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease.
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TP Knowles, JB Rowe, D Klenerman, G Meisl
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
(2025)
13
(doi: 10.1002/advs.202511297)
Yusuf Hamied Department of Chemistry
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