Yusuf Hamied Department of Chemistry

Dr Tom Wharton

Research Associate

Publications

On-resin assembly of cysteine-reactive linkers for controlled site-selective antibody bioconjugation.
S Krajcovicova, T Wharton, DR Spring
Nature protocols
(2026)
(doi: 10.1038/s41596-026-01376-4)
Boosting peptide half-life: enabling efficient generation of Fc–peptide conjugates
M Park, FM Dannheim, MA Papworth, R Kay, E Tsonou, D Trajkovski, SJ Walsh, D Hovdal, T Wharton, A-C Nassoy, JS Parker, DR Spring
Chem Sci
(2026)
(doi: 10.1039/d6sc02646j)
MMP-cleavable linker platform for tumour-responsive homo- and heterobivalent antibody-drug conjugates
AJ Counsell, SJ Walsh, N Ashman, M Park, FM Dannheim, TA King, T Wharton, JS Carroll, DR Spring
Chemical Science
(2025)
17
(doi: 10.1039/d5sc06664f)
Towards a glutathione-cleavable azobenzene linker for antibody-drug conjugates.
M Kapun, R Patel, M Park, FJ Pérez-Areales, KA Kostadinova, T Wharton, JS Carroll, DR Spring
Chemical Communications
(2025)
61
(doi: 10.1039/d5cc05824d)
A Platform for SpyCatcher Conjugation to Native Antibodies
S Krajcovicova, T Wharton, CL Driscoll, TA King, MR Howarth, DR Spring
Chemical science
(2025)
16
(doi: 10.1039/d5sc02286j)
Methods for the Generation of Single-Payload Antibody-Drug Conjugates.
T Wharton, DR Spring
Chemmedchem
(2025)
20
(doi: 10.1002/cmdc.202500132)
Advances in the Release of Amide-Containing Molecules
T Wharton, DR Spring
Chemistry (Weinheim an der Bergstrasse, Germany)
(2025)
31
(doi: 10.1002/chem.202404413)
Single-Payload Bioconjugation to Native Antibodies And A General Method for the Self-Immolative Release of Amide-Containing Molecules
T Wharton
(2024)
(doi: 10.17863/CAM.114785)
Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules
T Wharton, F Crawshay‐Williams, T Schober, RA Floto, DR Spring
Angewandte Chemie
(2024)
136
(doi: 10.1002/ange.202402267)
Unlocking Amides: A General Method for the Self-Immolative Release of Amide-Containing Molecules.
T Wharton, F Crawshay-Williams, T Schober, RA Floto, DR Spring
Angew Chem Int Ed Engl
(2024)
63
(doi: 10.1002/anie.202402267)

Research Group

Telephone number

01223 336361 (shared)

Email address

tw529@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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