Yusuf Hamied Department of Chemistry

Dr Tom Wharton

Research Associate

Publications

Recent advances in antibody-drug conjugates
JD Sydenham, T Wharton, DR Spring
Current Opinion in Chemical Biology
(2026)
94
(doi: 10.1016/j.cbpa.2026.102727)
On-resin assembly of cysteine-reactive linkers for controlled site-selective antibody bioconjugation.
S Krajcovicova, T Wharton, DR Spring
Nature Protocols
(2026)
(doi: 10.1038/s41596-026-01376-4)
Cysteine Re-bridging Using Divinyl Pyrimidine Reagents for the Generation of Antibody-Drug Conjugates
T Wharton, S Krajcovicova, DR Spring
Methods in Molecular Biology
(2026)
3009
(doi: 10.1007/978-1-0716-5112-4_10)
Boosting peptide half-life: enabling efficient generation of Fc–peptide conjugates
M Park, FM Dannheim, MA Papworth, R Kay, E Tsonou, D Trajkovski, SJ Walsh, D Hovdal, T Wharton, A-C Nassoy, JS Parker, DR Spring
Chemical science
(2026)
17
(doi: 10.1039/d6sc02646j)
MMP-cleavable linker platform for tumour-responsive homo- and heterobivalent antibody-drug conjugates
AJ Counsell, SJ Walsh, N Ashman, M Park, FM Dannheim, TA King, T Wharton, JS Carroll, DR Spring
Chemical science
(2025)
17
(doi: 10.1039/d5sc06664f)
Towards a glutathione-cleavable azobenzene linker for antibody-drug conjugates.
M Kapun, R Patel, M Park, FJ Pérez-Areales, KA Kostadinova, T Wharton, JS Carroll, DR Spring
Chemical communications (Cambridge, England)
(2025)
61
(doi: 10.1039/d5cc05824d)
A platform for SpyCatcher conjugation to native antibodies.
S Krajcovicova, T Wharton, CL Driscoll, TA King, MR Howarth, DR Spring
Chemical science
(2025)
16
(doi: 10.1039/d5sc02286j)
Methods for the Generation of Single‐Payload Antibody‐Drug Conjugates
T Wharton, DR Spring
ChemMedChem
(2025)
20
(doi: 10.1002/cmdc.202500132)
Advances in the Release of Amide-Containing Molecules.
T Wharton, DR Spring
Chemistry A European Journal
(2025)
31
(doi: 10.1002/chem.202404413)
Single-Payload Bioconjugation to Native Antibodies And A General Method for the Self-Immolative Release of Amide-Containing Molecules
T Wharton
(2024)
(doi: 10.17863/CAM.114785)

Research Group

Telephone number

01223 336361 (shared)

Email address

tw529@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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