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Yusuf Hamied Department of Chemistry

 

Professor of Physical Chemistry and Biophysics

1920 Professor of Physical Chemistry

Our research

We study the physical and chemical aspects of the behaviour of biopolymers and other soft systems. Much of our work has been focused on the physical aspects underlying the self-assembly of protein molecules. Self-organisation is the driving force generating complex matter in nature, and the process by which the machinery providing functionality in living systems is assembled. The goal of our research is to understand the physical and chemical factors which control the structures and dynamics of biomolecular assemblies, and the connections between the nanoscale characteristics of the component molecules and the physical properties of large-scale assemblies and their behaviour on a mesoscopic to macroscopic scale. The techniques used in our laboratory include biosensors, optical lithography, microfluidic devices and scanning probe microscopy and spectroscopy. We work both with natural and synthetic polymers and our interests range from fundamental chemical physics to technological applications in material science and molecular medicine.

Watch Professor Knowles discuss his research

Take a tour of the Sir Rodney Sweetnam laboratory

Publications

DNA-Liposome Hybrid Carriers for Triggered Cargo Release
KN Baumann, T Schröder, PS Ciryam, D Morzy, P Tinnefeld, TPJ Knowles, S Hernández-Ainsa
(2022)
Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates.
TJ Welsh, G Krainer, JR Espinosa, JA Joseph, A Sridhar, M Jahnel, WE Arter, KL Saar, S Alberti, R Collepardo-Guevara, TPJ Knowles
– Nano Lett
(2022)
22,
612
Microchip Free-Flow Electrophoresis for Bioanalysis, Sensing, and Purification
WE Arter, KL Saar, TW Herling, TPJ Knowles
(2022)
2394,
249
Universal lab-on-a-chip microfluidic spray deposition for bulk and single-molecule analytical methods on surfaces
AM Miller, SKR Chia, T Hakala, Z Toprakcioglu, M Vendruscolo, FS Ruggeri, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2022)
121,
351A
Single-molecule sizing through nano-cavity confinement
R Jacquat, G Krainer, Q Peter, AN Babar, O Vanderpoorten, C Xu, T Welsh, C Kaminski, U Keyser, J Baumberg, T Knowles
(2021)
2021.12.13.472369
Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of α-synuclein aggregates
S Chia, ZF Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo
(2021)
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma
MM Schneider, M Emmenegger, CK Xu, I Condado Morales, G Meisl, P Turelli, C Zografou, MR Zimmermann, BM Frey, S Fiedler, V Denninger, RP Jacquat, L Madrigal, A Ilsley, V Kosmoliaptsis, H Fiegler, D Trono, TP Knowles, A Aguzzi
– Life Sci Alliance
(2021)
5,
e202101270
2-photon-fabricated nano-fluidic traps for extended detection of single macromolecules and colloids in solution
O Vanderpoorten, AN Babar, G Krainer, RPB Jacquat, P Challa, Q Peter, Z Toprakcioglu, C Xu, U Keyser, J Baumberg, C Kaminski, T Knowles
(2021)
Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation.
DC Rodriguez Camargo, E Sileikis, S Chia, E Axell, K Bernfur, RL Cataldi, SIA Cohen, G Meisl, J Habchi, TPJ Knowles, M Vendruscolo, S Linse
– ACS Chem Neurosci
(2021)
12,
4406
Discovery of Potent Inhibitors of α-Synuclein Aggregation Using Structure-Based Iterative Learning
R Horne, E Andrzejewska, P Alam, F Brotzakis, A Srivastava, A Aubert, M Nowinska, R Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, T Knowles, M Vendruscolo
(2021)
2021.11.10.468009
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Research Interest Groups

Telephone number

01223 336344

Email address

tpjk2@cam.ac.uk