skip to content
Home

Yusuf Hamied Department of Chemistry

 

Professor Tuomas Knowles

Professor of Physical Chemistry and Biophysics

1920 Professor of Physical Chemistry

Our research

We study the physical and chemical aspects of the behaviour of biopolymers and other soft systems. Much of our work has been focused on the physical aspects underlying the self-assembly of protein molecules. Self-organisation is the driving force generating complex matter in nature, and the process by which the machinery providing functionality in living systems is assembled. The goal of our research is to understand the physical and chemical factors which control the structures and dynamics of biomolecular assemblies, and the connections between the nanoscale characteristics of the component molecules and the physical properties of large-scale assemblies and their behaviour on a mesoscopic to macroscopic scale. The techniques used in our laboratory include biosensors, optical lithography, microfluidic devices and scanning probe microscopy and spectroscopy. We work both with natural and synthetic polymers and our interests range from fundamental chemical physics to technological applications in material science and molecular medicine.

Watch Professor Knowles discuss his research

Take a tour of the Sir Rodney Sweetnam laboratory

Publications

A conformational switch controlling the toxicity of the prion protein
K Frontzek, M Bardelli, A Senatore, A Henzi, RR Reimann, S Bedir, M Marino, R Hussain, S Jurt, G Meisl, M Pedotti, F Mazzola, G Siligardi, O Zerbe, M Losa, T Knowles, A Lakkaraju, C Zhu, P Schwarz, S Hornemann, MG Holt, L Simonelli, L Varani, A Aguzzi
– Nature Structural & Molecular Biology
(2022)
29,
831
(doi: 10.1038/s41594-022-00814-7)
DNA–Liposome Hybrid Carriers for Triggered Cargo Release
KN Baumann, T Schröder, PS Ciryam, D Morzy, P Tinnefeld, TPJ Knowles, S Hernández-Ainsa
– ACS applied bio materials
(2022)
5,
3713
(doi: 10.1021/acsabm.2c002253713)
Structure-specific amyloid precipitation in biofluids.
M Rodrigues, P Bhattacharjee, A Brinkmalm, DT Do, CM Pearson, S De, A Ponjavic, JA Varela, K Kulenkampff, I Baudrexel, D Emin, FS Ruggeri, JE Lee, AR Carr, TPJ Knowles, H Zetterberg, TN Snaddon, S Gandhi, SF Lee, D Klenerman
– Nature chemistry
(2022)
14,
1045
(doi: 10.1038/s41557-022-00976-3)
Recent Advances in Microgels: From Biomolecules to Functionality
Y Xu, H Zhu, A Denduluri, Y Ou, NA Erkamp, R Qi, Y Shen, TPJ Knowles
– Small (Weinheim an der Bergstrasse, Germany)
(2022)
18,
e2200180
(doi: 10.1002/smll.202200180)
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions
M Kar, F Dar, TJ Welsh, LT Vogel, R Kühnemuth, A Majumdar, G Krainer, TM Franzmann, S Alberti, CAM Seidel, TPJ Knowles, AA Hyman, RV Pappu
– Proceedings of the National Academy of Sciences of the United States of America
(2022)
119,
e2202222119
(doi: 10.1073/pnas.2202222119)
Aging can transform single-component protein condensates into multiphase architectures.
A Garaizar, JR Espinosa, JA Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara
– Proceedings of the National Academy of Sciences
(2022)
119,
e2119800119
(doi: 10.1073/pnas.2119800119)
Kinetic profiling of therapeutic strategies for inhibiting the formation of amyloid oligomers.
TCT Michaels, AJ Dear, SIA Cohen, M Vendruscolo, TPJ Knowles
– The Journal of Chemical Physics
(2022)
156,
164904
(doi: 10.1063/5.0077609)
Analytical solution to the Flory-Huggins model
D Qian, T Michaels, T Knowles
(2022)
(doi: 10.1101/2022.04.23.489256)
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic.
R Limbocker, S Errico, D Barbut, TPJ Knowles, M Vendruscolo, F Chiti, M Zasloff
– Natural product reports
(2022)
39,
742
(doi: 10.1039/d1np00042j)
A Kinetic Map of the Influence of Biomimetic Lipid Membrane Models on Aβ42Aggregation
K Baumann, M Sanguanini, O Rimon, G Šneiderienė, H Greer, D Thacker, M Schneider, S Linse, T Knowles, M Vendruscolo
(2022)
2022.04.16.488542
(doi: 10.1101/2022.04.16.488542)
  • <
  • 17 of 70
  • >

Research Groups

Research Interest Groups

Telephone number

01223 336344

Email address

tpjk2@cam.ac.uk

College

St John's College

    Study at Cambridge

    About the University

    Research at Cambridge