Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Synthesis of the β-lactam antibiotic (+)- thienamycin via an intermediate π-allyltricarbonyliron lactone complex
– Tetrahedron
(1985)
41,
5871
Structural reappraisal of the limonoid insect antifeedant azadirachtin
– Journal of the Chemical Society, Chemical Communications
(1985)
968
(doi: 10.1039/c39850000968)
WITTIG AND HORNER-WITTIG COUPLING REACTIONS OF 2-SUBSTITUTED CYCLIC ETHERS AND THEIR APPLICATION TO SPIROKETAL SYNTHESIS
– Tetrahedron
(1985)
41,
3825
PREPARATION AND REACTIONS OF 2-BENZENESULPHONYLTETRAHYDROPYRAN
– Tetrahedron Letters
(1985)
26,
535
Total synthesis of the sesquiterpene (±)-hirsutene using an organoselenium-mediated cyclization reaction
– Tetrahedron
(1985)
41,
4765
Use of π-allyltricarbonyliron lactam complexes in the preparation of nocardicin derivatives: synthesis of (–)-3-oxo-1-[(p-benzyloxyphenyl)-benzyloxycarbonylmethyl]azetidin-2-one
– Journal of the Chemical Society, Perkin Transactions 1
(1985)
2375
(doi: 10.1039/P19850002375)
Synthesis of the northern hemisphere of the milbemycins using a new strategy for the formation of the C15 to C16 bond.
– Tetrahedron Letters
(1985)
26,
5837
SYNTHETIC APPLICATIONS OF YNES, ENES AND ONES - ORGANOSELENIUM-MEDIATED CYCLIZATION REACTIONS IN ORGANIC-SYNTHESIS
– CHEMISTRY & INDUSTRY
(1985)
101
Preparation of vinylic sulphones by Peterson olefination using phenyl trimethylsilylmethyl sulphone
– Journal of the Chemical Society, Perkin Transactions 1
(1985)
1949
(doi: 10.1039/p19850001949)
The use of t-butyl acetothioacetate as a route to bis-β-ketomacrolides
– Chemical Communications
(1985)
1805
(doi: 10.1039/c39850001805)
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