Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Dispiroketals in synthesis (Part 17): Regioselective protection of D-glucopyranoside D-galactopyranoside and D-mannopyranoside substrates.
– Tetrahedron Asymmetry
(1994)
5,
2609
Diastereoselective addition reactions to carbonyl groups in the side-chain of π-allytricarbonyliron lactone complexes
– Journal of the Chemical Society Chemical Communications
(1994)
1931
(doi: 10.1039/C39940001931)
Dispiroketals in synthesis (part 9): Resolution of 1,2-diols using a C2-symmetric diphenyltetrahydrobipyran.
– Tetrahedron: Asymmetry
(1994)
5,
553
(doi: 10.1016/0957-4166(94)80016-2)
Dispiroketals in synthesis (part 10): Further reactions of dispoke protected lactate and glycolate enolates
– Tetrahedron
(1994)
50,
7157
Dispiroketals in synthesis (part 6): Highly stereoselective alkylation of dispiroketal protected lactate and glycolate enolates
– Tetrahedron Letters
(1994)
35,
769
Dispiroketals in Synthesis (Part 15): Simultaneous Enantioselective and Regioselective Protection of Glycerol by Reaction with C2 Symmetric (4S,4′S)-Dimethyl-bis-dihydropyran
– Synthesis
(1994)
1994,
1275
(doi: 10.1055/s-1994-25680)
Dispiroketals in synthesis (Part 5): A new opportunity for oligosaccharide synthesis using differentially activated glycosyl donors and acceptors
– Tetrahedron Letters
(1993)
34,
8523
Selective Acylation and Alkylation Reactions of Diols Using Dibutyltin Dimethoxide
– Synlett
(1993)
1993,
913
(doi: 10.1055/s-1993-22650)
Total synthesis of the spiroketal macrolide (+) milbemycin α1
– Tetrahedron Letters
(1993)
34,
7479
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