Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Tetrapropylammonium Perruthenate, Pr4N+RuO4 -, TPAP: A Catalytic Oxidant for Organic Synthesis
Synthesis
(1994)
1994
639
(doi: 10.1055/s-1994-25538)
Diastereoselective addition reactions to carbonyl groups in the side-chain of π-allytricarbonyliron lactone complexes
Journal of the Chemical Society Chemical Communications
(1994)
1931
(doi: 10.1039/C39940001931)
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .16. SYNTHESIS OF SEVERAL DERIVATIVES OF AZADIRACHTIN CONTAINING FLUORESCENT OR IMMUNOGENIC REPORTER GROUPS
Tetrahedron
(1994)
50
8871
Dispiroketals in synthesis (Part 17): Regioselective protection of D-glucopyranoside D-galactopyranoside and D-mannopyranoside substrates.
Tetrahedron Asymmetry
(1994)
5
2609
Dispiroketals in synthesis (part 6): Highly stereoselective alkylation of dispiroketal protected lactate and glycolate enolates
Tetrahedron Letters
(1994)
35
769
DISPIROKETALS IN SYNTHESIS .9. RESOLUTION OF 1,2-DIOLS USING A C-2-SYMMETRICAL DIPHENYLTETRAHYDROBIPYRAN
Tetrahedron Asymmetry
(1994)
5
553
(doi: 10.1016/0957-4166(94)80016-2)
Dispiroketals in synthesis (part 10): Further reactions of dispoke protected lactate and glycolate enolates
Tetrahedron
(1994)
50
7157
DISPIROKETALS IN SYNTHESIS .8. REGIOSELECTIVE PROTECTION OF D-GLUCOPYRANOSE SUBSTRATES
Tetrahedron Letters
(1994)
35
777
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .17. SYNTHESIS OF MODEL COMPOUNDS OF AZADIRACHTIN - UNUSUAL EFFECT OF REMOTE SUBSTITUENTS ON THE COURSE OF THE OXIDATIVE RING CONTRACTION REACTION
Tetrahedron
(1994)
50
11553
Dispiroketals in synthesis (part 7): Protection of D-glucopyranose substrates
Tetrahedron Letters
(1994)
35
773
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