Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Synthesis of glycans from the glycodelins: Two undeca-, two deca-, three nona-, an octa- and a heptasaccharide
– Chemistry A European Journal
(1999)
5,
3326
Nitrogen atom transfer from a novel nitridomanganese complex for the amination of silyl enol ether and glycal derivatives
– Chemtracts
(1999)
12,
27
Clean synthesis of a-bromo ketones and their utilisation in the synthesis of 2-aIkoxy-2,3-dihydro-2-aryl-l,4-benzodioxanes, 2-amino-4-aryI-l,3-thiazoles and piperidino-2-amino-l,3-thiazoles using polymer-supported reagents
– Journal of the Chemical Society Perkin Transactions 1
(1999)
2425
(doi: 10.1039/a905616e)
Tritiated dihydroazadirachtin binging to Schistocerca gregaria testes and Spodoptera Sf9 cells suggests a similar cellular mechanism of action for azadirachtin
– AZADIRACHTA INDICA A. JUSS.
(1999)
247
Assembly of dendritic glycoclusters from monomeric mannose building blocks
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1998)
3913
(doi: 10.1039/a807621i)
Total synthesis of the protein phosphatase inhibitor okadaic acid
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1998)
3907
(doi: 10.1039/a807957i)
Characterization of azadirachtin binding to Sf9 nuclei in vitro
– Archives of Insect Biochemistry and Physiology
(1998)
34,
461
Total synthesis of roflamycoin, an oxopolyene macrolide antibiotic
– Chemtracts
(1998)
11,
1005
Double diastereodifferentiation in the Mukaiyama aldol reactions of π-allyltricarbonyliron lactone complexes: 1,7- vs. 1,2-asymmetric induction
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1998)
3349
(doi: 10.1039/a805996i)
Clean six-step synthesis of a piperidino-thiomorpholine library using polymer-supported reagents
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1998)
3127
(doi: 10.1039/a805997g)
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