Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A novel decomplexation of π-allyltricarbonyliron lactone complexes using borohydride reagents:: a new route to stereodefined acyclic 1,5-diols and 1,5,7-triols
Chemical Communications
(1998)
229
(doi: 10.1039/a707155h)
Highly diastereoselective synthesis of β-hydroxy carbonyl compounds using π-allyltricarbonyliron lactone complexes: a formal 1,7-asymmetric induction of chirality in a Mukaiyama aldol reaction
Chemical Communications
(1998)
227
(doi: 10.1039/a707153a)
Tuning glycoside reactivity: New tool for efficient oligosaccharide synthesis
Journal of the Chemical Society, Perkin Transactions 1
(1998)
51
(doi: 10.1039/a705275h)
Synthesis of isoxazolidines using polymer supported perruthenate (PSP)
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1998)
1
(doi: 10.1039/a707340b)
Polymer Supported Perruthenate (PSP): Clean Oxidation of Primary Alcohols to Carbonyl Compounds Using Oxygen as Cooxidant
Synthesis
(1998)
1998
977
(doi: 10.1055/s-1998-2106)
Studies Towards the Synthesis of the C29-C51 Fragment of Altohyrtin A
Synlett
(1998)
1998
991
(doi: 10.1055/s-1998-3140)
Double diastereodifferentiation in the Mukaiyama aldol reactions of π-allyltricarbonyliron lactone complexes:: 1,7- vs. 1,2-asymmetric induction
Journal of the Chemical Society, Perkin Transactions 1
(1998)
3349
(doi: 10.1039/a805996i)
Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives of lactols
Synlett
(1998)
1998
1091
(doi: 10.1055/s-1998-1866)
One-pot synthesis of penta- and hepta-saccharides from monomeric mannose building blocks using the principles of orthogonality and reactivity tuning
Synlett
(1998)
1998
440
(doi: 10.1055/s-1998-1659)
(1′S,2′S)-methyl-3O,4O-(1′,2′-dimethoxycyclohexane-1′,2′-diyl)-α-D-mannopyranoside [α-D-Mannopyranoside, methyl 3,4-O-(1,2-dimethoxy- 1,2-cyclohexanediyl)-, [3[S (S)]]-]
Organic Syntheses
(1998)
75
170
(doi: 10.15227/orgsyn.075.0170)
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