Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

A new route to functionalised π-allyltricarbonyliron lactam complexes from aziridines and their use in stereoselective synthesis and oxidative conversion to β-lactams

SV Ley, B Middleton

Chemical Communications

(1998)

1995

(doi: 10.1039/a806236f)

Molybdenum(II)- and tungsten(II)-catalyzed allylic substitution

AV Malkov, IR Baxendale, DJ Mansfield, P Kocovsky

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(1998)

216

U548

Use of polymer supported reagents for clean multi-step organic synthesis: Preparation of amines and amine derivatives from alcohols for use in compound library generation

SV Ley, MH Bolli, B Hinzen, A-G Gervois, BJ Hall

Journal of the Chemical Society, Perkin Transactions 1

(1998)

2239

(doi: 10.1039/a803611j)

Synthesis of the acyltetronic acid ionophore tetronasin (ICI M139603)

SV Ley, DS Brown, JA Clase, AJ Fairbanks, IC Lennon, HMI Osborn, ESE StokeséOwen, DJ Wadsworth

Journal of the Chemical Society Perkin Transactions 1

(1998)

2259

(doi: 10.1039/a804170i)

Clean three-step synthesis of 4,5-dihydro-1H-pyrazoles starting from alcohols using polymer supported reagents

F Haunert, MH Bolli, B Hinzen, SV Ley

Journal of the Chemical Society, Perkin Transactions 1

(1998)

2235

(doi: 10.1039/a803609h)

Development of a polymer bound Wittig reaction and use in multi-step organic synthesis for the overall conversion of alcohols to beta-hydroxyamines

MH Bolli, SV Ley

J CHEM SOC PERK T 1

(1998)

2243

(doi: 10.1039/a803612h)

Stereoelectronic effects in the reactions of conformationally restricted, substituted cyclohexane-1,2-diones with 1,2-diols

R Lenz, SV Ley, DR Owen, SL Warriner

Tetrahedron Asymmetry

(1998)

2471

(doi: 10.1016/s0957-4166(98)00227-4)

Mukaiyama aldol reactions of π-allyltricarbonyliron lactone and lactam complexes bearing trimethylsilyl enol ether side-chains.: Not just formal, but genuine 1,7 induction of chirality

SV Ley, B Middleton, JM Worrall

Chemical Communications

(1998)

1339

(doi: 10.1039/a802878h)

Highly diasteroselective synthesis of β-hydroxy carbonyl compounds using π-allyltricarbonyliron lactone complexes:: a formal 1,7-asymmetric induction of chirality in a Mukaiyama aldol reaction (pg 227, 1998)

SV Ley, LR Cox

CHEMICAL COMMUNICATIONS

(1998)

851

A novel decomplexation of π-allyltricarbonyliron lactone complexes using borohydride reagents:: a new route to stereodefined acyclic 1,5-diols and 1,5,7-triols (pg 229, 1998)

SV Ley, S Burckhardt, LR Cox, JM Worrall

CHEMICAL COMMUNICATIONS

(1998)

851

Professor Steve Ley CBE FRS FMedSci

Director of Research

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