Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Actions of azadirachtin, a plant allelochemical, against insects
– Pesticide Science
(1999)
54,
277
Polymer-supported hypervalent iodine reagents in ‘clean’ organic synthesis with potential application in combinatorial chemistry
– Journal of the Chemical Society Perkin Transactions 1
(1999)
669
(doi: 10.1039/a809799b)
Molybdenum(II)-Catalyzed Allylation of Electron-Rich Aromatics and Heteroaromatics
– The Journal of Organic Chemistry
(1999)
64,
2751
(doi: 10.1021/jo982178y)
Molybdenum(II)- and Tungsten(II)-Catalyzed Allylic Substitution
– The Journal of Organic Chemistry
(1999)
64,
2737
(doi: 10.1021/jo9821776)
1,7-Induction of chirality in Mukaiyama aldol reactions using π-allyltricarbonyliron lactone and lactam complexes as chiral templates
– Tetrahedron
(1999)
55,
3515
Chemical synthesis of the N-glycans of gp63, the major surface glycoprotein from Leishmania mexicana amazonensis
– Journal of the Chemical Society, Perkin Transactions 1
(1999)
375
(doi: 10.1039/a809798d)
Clean five-step synthesis of an array of 1,2,3,4-tetra-substituted pyrroles using polymer-supported reagents
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1999)
107
(doi: 10.1039/a809345h)
Rapid assembly of oligosaccharides: Total synthesis of a glycosylphosphatidylinositol anchor of Trypanosoma brucei
– Angew Chem Int Ed Engl
(1999)
37,
3423
Synthesis of glycans from the glycodelins: Two undeca-, two deca-, three nona-, an octa- and a heptasaccharide
– Chemistry - A European Journal
(1999)
5,
3326
Chemistry of Insect Antifeedants from Azadirachta indica (Part 22): Functionalisation of the Decalin Fragment of Azadirachtin via a Claisen Rearrangement Reaction
– Synlett
(1999)
1999,
1295
(doi: 10.1055/s-1999-2802)
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