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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Non-metal-catalysed intramolecular alkyne cyclotrimerization reactions promoted by focussed microwave heating in batch and flow modes.
S Saaby, IR Baxendale, SV Ley
– Organic & biomolecular chemistry
(2005)
3,
3365
A phase-switch purification approach for the expedient removal of tagged reagents and scavengers following their application in organic synthesis.
J Siu, IR Baxendale, RA Lewthwaite, SV Ley
– Organic & Biomolecular Chemistry
(2005)
3,
3140
Azadirachtin Disrupts Formation of Organised Microtubule Arrays during Microgametogenesis of Plasmodium berghei
O Billker, MK Shaw, IW Jones, SV Ley, AJ Mordue, RE Sinden
– J Eukaryot Microbiol
(2005)
49,
489
The use of a continuous flow-reactor employing a mixed hydrogen–liquid flow stream for the efficient reduction of imines to amines
S Saaby, KR Knudsen, M Ladlow, SV Ley
– Chemical communications (Cambridge, England)
(2005)
2909
Copper- and palladium-containing perovskites: Catalysts for the Ullmann and Sonogashira reactions (pg 1291, 2005)
S Lohmann, SP Andrews, BJ Burke, MD Smith, JP Attfield, H Tanaka, K Kaneko, SV Ley
– SYNLETT
(2005)
1490
The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating
IR Baxendale, SV Ley, M Martinelli
– Tetrahedron
(2005)
61,
5323
Total synthesis of antascomicin B
DEA Brittain, CM Griffiths-Jones, MR Linder, MD Smith, C McCusker, JS Barlow, R Akiyama, K Yasuda, SV Ley
– Angew Chem Int Ed Engl
(2005)
44,
2732
Copper- and Palladium-Containing Perovskites: Catalysts for the Ullmann and Sonogashira Reactions
S Lohmann, SP Andrews, BJ Burke, MD Smith, JP Attfield, H Tanaka, K Kaneko, SV Ley
– Synlett
(2005)
2005,
1291
Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating
IR Baxendale, SV Ley
– J Comb Chem
(2005)
7,
483
Synthesis of the alkaloid natural products (+)-plicane and (-)-obliquine, using polymer-supported reagents and scavengers
IR Baxendale, SV Ley
– Industrial and Engineering Chemistry Research
(2005)
44,
8588
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk