Professor Steve Ley CBE FRS FMedSci | Page 47 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Non-metal-catalysed intramolecular alkyne cyclotrimerization reactions promoted by focussed microwave heating in batch and flow modes

S Saaby, IR Baxendale, SV Ley

– Org Biomol Chem

(2005)

3,

3365

(doi: 10.1039/b509540a)

A phase-switch purification approach for the expedient removal of tagged reagents and scavengers following their application in organic synthesis

J Siu, IR Baxendale, RA Lewthwaite, SV Ley

– Organic & Biomolecular Chemistry

(2005)

3,

3140

(doi: 10.1039/b503778f)

Azadirachtin disrupts formation of organised microtubule arrays during microgametogenesis of Plasmodium berghei.

O Billker, MK Shaw, IW Jones, SV Ley, AJ Mordue, RE Sinden

– The Journal of eukaryotic microbiology

(2005)

49,

489

(doi: 10.1111/j.1550-7408.2002.tb00234.x)

The use of a continuous flow-reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines.

S Saaby, KR Knudsen, M Ladlow, SV Ley

– Chem Commun (Camb)

(2005)

2909

(doi: 10.1039/b504854k)

Copper- and palladium-containing perovskites: Catalysts for the Ullmann and Sonogashira reactions (pg 1291, 2005)

S Lohmann, SP Andrews, BJ Burke, MD Smith, JP Attfield, H Tanaka, K Kaneko, SV Ley

– SYNLETT

(2005)

1490

(link to publication)

The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating

IR Baxendale, SV Ley, M Martinelli

– Tetrahedron

(2005)

61,

5323

(doi: 10.1016/j.tet.2005.03.062)

Total synthesis of antascomicin B.

DEA Brittain, CM Griffiths-Jones, MR Linder, MD Smith, C McCusker, JS Barlow, R Akiyama, K Yasuda, SV Ley

– Angew Chem Int Ed Engl

(2005)

44,

2732

(doi: 10.1002/anie.200500174)

Copper- and Palladium-Containing Perovskites: Catalysts for the Ullmann and Sonogashira Reactions

S Lohmann, SP Andrews, BJ Burke, MD Smith, JP Attfield, H Tanaka, K Kaneko, SV Ley

– Synlett

(2005)

2005,

1291

(doi: 10.1055/s-2005-865233)

Formation of 4-Aminopyrimidines via the Trimerization of Nitriles Using Focused Microwave Heating

IR Baxendale, SV Ley

– ACS Combinatorial Science

(2005)

7,

483

(doi: 10.1021/cc049826d)

Synthesis of the Alkaloid Natural Products (+)-Plicane and (−)-Obliquine, Using Polymer-Supported Reagents and Scavengers †

IR Baxendale, SV Ley

– Industrial & Engineering Chemistry Research

(2005)

44,

8588

(doi: 10.1021/ie048822i)