Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Highly Diastereoselective Desymmetrisation of Cyclicmeso-Anhydrides and Derivatisation to Mono-Protected 1,4-Diols
Synlett
(2005)
646
(doi: 10.1055/s-2005-862393)
A homo-proline tetrazole as an improved organocatalyst for the asymmetric Michael addition of carbonyl compounds to nitro-olefins
Synlett
(2005)
611
(doi: 10.1055/s-2005-862392)
A highly automated, polymer-assisted strategy for the preparation of 2-alkylthiobenzimidazoles and N,N′-dialkylbenzimidazolin-2-ones
J Comb Chem
(2005)
7
385
(doi: 10.1021/cc049832+)
Synthesis of a Ceramide Sphingolipid as a Potential Sex Pheromone of the Hair CrabErimacrus isenbeckiiUsing Butane-2,3-diacetal Desymmetrised Glycolic Acid Building Blocks
Synlett
(2005)
481
(doi: 10.1055/s-2005-862361)
The total synthesis of the annonaceous acetogenin 10-hydroxyasimicin
Angew Chem Int Ed Engl
(2005)
44
580
(doi: 10.1002/anie.200462264)
Supported Reagents and Scavengers in Multi-step Organic Synthesis
(2005)
53
Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions.
Organic & biomolecular chemistry
(2004)
3
84
(doi: 10.1039/b414742a)
Studies on the generation of enolate anions from butane-2,3-diacetal protected glycolic acid derivatives and subsequent highly diastereoselective coupling reactions with aldehydes and acid chlorides
Organic and Biomolecular Chemistry
(2004)
2
3618
(doi: 10.1039/b412790k)
Preparation of enantiopure butane-2,3-diacetals of glycolic acid and alkylation reactions leading to alpha-hydroxyacid and amide derivatives.
Org. Biomol. Chem.
(2004)
2
3608
(doi: 10.1039/b412788a)
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