Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Influence of microwave irradiation on the reaction of MgO and Al2O3 slurries to form layered double hydroxide
SJ Mitchell, IR Baxendale, W Jones
ABSTR PAP AM CHEM S
(2007)
233
Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin.
SP Andrews, MM Tait, M Ball, SV Ley
Organic & Biomolecular Chemistry
(2007)
5
(doi: 10.1039/b702481a)
Optimisation of conditions for O-benzyl and N-benzyloxycarbonyl protecting group removal using an automated flow hydrogenator
KR Knudsen, J Holden, SV Ley, M Ladlow
Advanced Synthesis & Catalysis
(2007)
349
(doi: 10.1002/adsc.200600558)
Chemical Variation of Natural‐Product‐Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives
L-G Milroy, G Zinzalla, G Prencipe, P Michel, SV Ley, M Gunaratnam, M Beltran, S Neidle
Angew Chem Int Ed Engl
(2007)
46
(doi: 10.1002/anie.200604688)
Chemical Variation of Natural‐Product‐Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives
L Milroy, G Zinzalla, G Prencipe, P Michel, SV Ley, M Gunaratnam, M Beltran, S Neidle
Angewandte Chemie
(2007)
119
(doi: 10.1002/ange.200604688)
Identification of a putative azadirachtin-binding complex from Drosophila Kc167 cells
SL Robertson, W Ni, TS Dhadialla, AJ Nisbet, C McCusker, SV Ley, W Mordue, AJ Mordue 'Luntz'
Arch Insect Biochem Physiol
(2007)
64
(doi: 10.1002/arch.20171)
Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system.
CM Griffiths-Jones, MD Hopkin, D Jönsson, SV Ley, DJ Tapolczay, E Vickerstaffe, M Ladlow
Journal of Combinatorial Chemistry
(2007)
9
(doi: 10.1021/cc060152b)
Total synthesis of rapamycin
ML Maddess, MN Tackett, H Watanabe, PE Brennan, CD Spilling, JS Scott, DP Osborn, SV Ley
Angewandte Chemie International Edition
(2007)
46
(doi: 10.1002/anie.200604053)
Total synthesis of thapsigargin, a potent SERCA pump inhibitor
M Ball, SP Andrews, F Wierschem, E Cleator, MD Smith, SV Ley
Organic letters
(2007)
9
(doi: 10.1021/ol062947x)
New avenues to efficient chemical synthesis
IR Baxendale, SV Ley
(2007)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

Privacy and cookie policy

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge