Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Optimisation of conditions for O-benzyl and N-benzyloxycarbonyl protecting group removal using an automated flow hydrogenator

KR Knudsen, J Holden, SV Ley, M Ladlow

Advanced Synthesis and Catalysis

(2007)

349

535

(doi: 10.1002/adsc.200600558)

Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives.

L-G Milroy, G Zinzalla, G Prencipe, P Michel, SV Ley, M Gunaratnam, M Beltran, S Neidle

Angew Chem Int Ed Engl

(2007)

2493

(doi: 10.1002/anie.200604688)

Chemical Variation of Natural‐Product‐Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives

L Milroy, G Zinzalla, G Prencipe, P Michel, SV Ley, M Gunaratnam, M Beltran, S Neidle

Angewandte Chemie

(2007)

119

2545

(doi: 10.1002/ange.200604688)

Identification of a putative azadirachtin-binding complex from Drosophila Kc167 cells

SL Robertson, W Ni, TS Dhadialla, AJ Nisbet, C McCusker, SV Ley, W Mordue, AJ Mordue 'Luntz'

Arch Insect Biochem Physiol

(2007)

200

(doi: 10.1002/arch.20171)

Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system.

CM Griffiths-Jones, MD Hopkin, D Jönsson, SV Ley, DJ Tapolczay, E Vickerstaffe, M Ladlow

Journal of Combinatorial Chemistry

(2007)

422

(doi: 10.1021/cc060152b)

Total synthesis of rapamycin

ML Maddess, MN Tackett, H Watanabe, PE Brennan, CD Spilling, JS Scott, DP Osborn, SV Ley

Angewandte Chemie International Edition

(2007)

591

(doi: 10.1002/anie.200604053)

Total synthesis of thapsigargin, a potent SERCA pump inhibitor

M Ball, SP Andrews, F Wierschem, E Cleator, MD Smith, SV Ley

Organic letters

(2007)

663

(doi: 10.1021/ol062947x)

Natural Products as an Inspiration for the Discovery of New High Throughput Chemical Synthesis Tools In Drug Discovery & Development

IR Baxendale, RM Myers, DA Longbottom, SV Ley

(2007)

New avenues to efficient chemical synthesis

IR Baxendale, SV Ley

(2007)

151

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.

IR Baxendale, SV Ley, CD Smith, GK Tranmer

Chem Commun (Camb)

(2006)

4835

(doi: 10.1039/b612197g)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Group

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College

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