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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Synthesis of antifeedants for insects: novel behaviour-modifying chemicals from plants.
SV Ley
– Ciba Found Symp
(2007)
154,
80
(doi: 10.1002/9780470514009.ch7)
A relay route for the synthesis of azadirachtin.
GE Veitch, E Beckmann, BJ Burke, A Boyer, C Ayats, SV Ley
– Angewandte Chemie (International ed. in English)
(2007)
46,
7633
(doi: 10.1002/anie.200703028)
Synthesis of azadirachtin: A long but successful journey
GE Veitch, E Beckmann, BJ Burke, A Boyer, SL Maslen, SV Ley
– Angewandte Chemie (International ed. in English)
(2007)
46,
7629
(doi: 10.1002/anie.200703027)
A sequential enantioselective, organocatalytic route to chiral 1,2-oxazines and chiral pyridazines.
S Kumarn, AJ Oelke, DM Shaw, DA Longbottom, SV Ley
– Org Biomol Chem
(2007)
5,
2678
(doi: 10.1039/b708646f)
ORGN 121-Toward the total synthesis of azadirachtin
A Boyer, E Beckmann, GE Veitch, BJ Burke, SV Ley
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2007)
234,
(link to publication)
Chiral glycolate equivalents for the asymmetric synthesis of α-hydroxycarbonyl compounds
SV Ley, TD Sheppard, RM Myers, MS Chorghade
– Bulletin of the Chemical Society of Japan
(2007)
80,
1451
(doi: 10.1246/bcsj.80.1451)
Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines
CJ Smith, FJ Iglesias-Sigüenza, IR Baxendale, SV Ley
– Organic and Biomolecular Chemistry
(2007)
5,
2758
(doi: 10.1039/b709043a)
Total synthesis of five thapsigargins:: Guaianolide natural products exhibiting sub-nanomolar SERCA inhibition
SP Andrews, M Ball, F Wierschem, E Cleator, S Oliver, K Högenauer, O Simic, A Antonello, U Hünger, MD Smith, SV Ley
– Chemistry A European Journal
(2007)
13,
5688
(doi: 10.1002/chem.200700302)
Total synthesis of potent antifungal marine bisoxazole natural products bengazoles A and B.
JA Bull, EP Balskus, RAJ Horan, M Langner, SV Ley
– Chemistry – A European Journal
(2007)
13,
5515
(doi: 10.1002/chem.200700033)
Pharmaceutical Strategy and Innovation: An Academics Perspective
IR Baxendale, JJ Hayward, SV Ley, GK Tranmer
– ChemMedChem
(2007)
2,
768
(doi: 10.1002/cmdc.200700008)
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Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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