Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products

Publications
The synthesis of azadirachtin: A potent insect antifeedant
Chemistry - A European Journal
(2008)
14
10683
(doi: 10.1002/chem.200801103)
A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor.
Journal of Combinatorial Chemistry
(2008)
10
851
(doi: 10.1021/cc800070a)
Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Pyrroles
Synlett
(2008)
2008
2597
(doi: 10.1055/s-0028-1083504)
Enantiopure 2-substituted glyceraldehyde derivatives by aza-Claisen rearrangement or C-alkylation of enamines.
Org Lett
(2008)
10
4537
(doi: 10.1021/ol8018242)
A tribute to Professor Ryoji!Noyori on the occasion of his 70th birthday
ADVANCED SYNTHESIS & CATALYSIS
(2008)
350
1925
The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor
Synlett
(2008)
2008
2111
(doi: 10.1055/s-2008-1078026)
New tools for molecule makers: Emerging technologies
VDI Berichte
(2008)
5
Magnesium nitride as a convenient source of ammonia: Preparation of primary amides
Organic Letters
(2008)
10
3623
(doi: 10.1021/ol801398z)
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