Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

The azadirachtin story.
GE Veitch, A Boyer, SV Ley
Angew Chem Int Ed Engl
(2008)
47
The synthesis of azadirachtin: A potent insect antifeedant
SV Ley, A Abad-Somovilla, JC Anderson, C Ayats, R Bänteli, E Beckmann, A Boyer, MG Brasca, A Brice, HB Broughton, BJ Burke, E Cleator, D Craig, AA Denholm, RM Denton, T Durand-Reville, LB Gobbi, M Göbel, BL Gray, RB Grossmann, CE Gutteridge, N Hahn, SL Harding, DC Jennens, L Jennens, PJ Lovell, HJ Lovell, ML de la Puente, HC Kolb, W-J Koot, SL Maslen, CF McCusker, A Mattes, AR Pape, A Pinto, D Santafianos, JS Scott, SC Smith, AQ Somers, CD Spilling, F Stelzer, PL Toogood, RM Turner, GE Veitch, A Wood, C Zumbrunn
Chemistry - A European Journal
(2008)
14
A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor.
IR Baxendale, SV Ley, CD Smith, L Tamborini, AF Voica
Journal of Combinatorial Chemistry
(2008)
10
Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Pyrroles
G Veitch, K Bridgwood, K Rands-Trevor, S Ley
Synlett
(2008)
2008
Enantiopure 2-substituted glyceraldehyde derivatives by aza-Claisen rearrangement or C-alkylation of enamines.
KL Bridgwood, CC Tzschucke, M O'Brien, S Wittrock, JM Goodman, JE Davies, AWJ Logan, MRM Hüttl, SV Ley
Org Lett
(2008)
10
Organic Chemistry in Microreactors
T Fukuyama, T Rahman, I Ryu, IR Baxendale, JJ Hayward, S Lanners, SV Ley, CD Smith, B Ahmed‐Omer, T Wirth, V Hessel, P Löb, H Löwe, K Koch, FPJT Rutjes, JCM van Hest
(2008)
A tribute to Professor Ryoji!Noyori on the occasion of his 70th birthday
JP Richmond, M Banwell, D Bellus, K Muniz, K Narasaka, Y Okamoto, J Okuda, M Schlosser, I Shinkai, K Tatsuta, G van Koten, X-Z You, VK Aggarwal, T Aida, H Alper, C Bai, K Bhattacharyya, H-U Blaser, B Pugin, F Spindler, JM Brown, SL Buchwald, ASC Chan, N Chatani, SE Denmark, F Diederich, MP Doyle, G Fu, A Fujishima, S Hanessian, S Hashimoto, M Hayashi, T Hiyama, P Hofmann, Z Hou, T Imamoto, K Izawa, E Jacobsen, T Katsuki, S Kim, S Kobayashi, K Komatsu, H Kumobayashi, EP Kuendig, E Lee, W Leitner, SV Ley, B Lipshutz, Y Lu, K Maruoka, S-I Murahashi, S Murai, KC Nicolaou, H Nishiyama, T Ohkuma, T Ohta, K Oshima, J Otera, A Pfaltz, MT Reetz, A Ricci, M Sawamoto, M Scalone, KB Sharpless, R Sheldon, V Snieckus, M Sodeoka, M Tokunaga, K Tomioka, Y Umezawa, Y Uozumi, C-H Wong, HNC Wong, Y Yamamoto, D Zhu
ADVANCED SYNTHESIS & CATALYSIS
(2008)
350
The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor
S Ley, M Baumann, I Baxendale
Synlett
(2008)
2008
New tools for molecule makers: Emerging technologies
SV Ley
VDI Berichte
(2008)
Magnesium nitride as a convenient source of ammonia: Preparation of primary amides
GE Veitch, KL Bridgwood, SV Ley
Organic Letters
(2008)
10

Research Group

Telephone number

01223 336398

Email address