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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Selenium-mediated cyclization reactions of alkenyl-substituted β-ketoesters
WP JACKSON, SV LEY, AJ WHITTLE
– Journal of the Chemical Society Chemical Communications
(1980)
1173
Conversion of thiocarbonyl compounds into their corresponding oxo-derivatives using benzeneseleninic anhydride
NJ CUSSANS, SV LEY, DHR BARTON
– Journal of the Chemical Society, Perkin Transactions 1
(1980)
1650
New cyclization procedure for alkenyl-substituted β-dicarbonyl compounds using N -phenylselenophthalimide
WP JACKSON, SV LEY, JA MORTON
– J. Chem. Soc., Chem. Commun.
(1980)
1028
Thermal decomposition of tricarbonyliron lactone complexes
GD ANNIS, SV LEY, CR SELF, R SIVARAMAKRISHNAN
– Journal of the Chemical Society Chemical Communications
(1980)
299
CATALYTIC-OXIDATION OF THIOCARBONYL COMPOUNDS INVOLVING THE USE OF 1,2-DIBROMOTETRACHLOROETHANE AS A BROMINATING REAGENT FOR DIARYL TEII SPECIES
SV LEY, CA MEERHOLZ, DHR BARTON
– Tetrahedron Letters
(1980)
21,
1785
Synthesis of a substituted cis-decalin as a potential insect antifeedant
WP JACKSON, SV LEY
– Journal of the Chemical Society, Chemical Communications
(1979)
732
Bis(p-methoxyphenyl) telluroxide: A new, mild oxidising agent
DHR BARTON, SV LEY, CA MEERHOLZ
– Journal of the Chemical Society Chemical Communications
(1979)
755
Isolation, Characterisation and Oxidation of Isomeric Ferrelactone Complexes.
GD ANNIS, SV LEY, R SIVARAMAKRISHNAN, AM ATKINSON, D ROGERS, DJ WILLIAMS
– Journal of Organometallic Chemistry
(1979)
182,
c11
The crystal structure of 3-epicaryoptin and the reversal of the currently accepted absolute configuration of clerodin
D ROGERS, GG UNAL, DJ WILLIAMS, SV LEY, GA SIM, BS JOSHI, KR RAVINDRANATH
– Chemical Communications
(1979)
97
Preparation of episulphides from alkenes via succinimide-N-sulphenyl chloride or phthalimide-N-sulphenyl chloride adducts
MU BOMBALA, SV LEY
– Journal of the Chemical Society, Perkin Transactions 1
(1979)
3013
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk