Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Selenium-mediated cyclization reactions of alkenyl-substituted β-ketoesters
– Journal of the Chemical Society Chemical Communications
(1980)
1173
(doi: 10.1039/C39800001173)
Conversion of thiocarbonyl compounds into their corresponding oxo-derivatives using benzeneseleninic anhydride
– Journal of the Chemical Society, Perkin Transactions 1
(1980)
1650
(doi: 10.1039/p19800001650)
New cyclization procedure for alkenyl-substituted β-dicarbonyl compounds using N -phenylselenophthalimide
– J. Chem. Soc., Chem. Commun.
(1980)
1028
(doi: 10.1039/C39800001028)
Thermal decomposition of tricarbonyliron lactone complexes
– Journal of the Chemical Society Chemical Communications
(1980)
299
(doi: 10.1039/c39800000299)
CATALYTIC-OXIDATION OF THIOCARBONYL COMPOUNDS INVOLVING THE USE OF 1,2-DIBROMOTETRACHLOROETHANE AS A BROMINATING REAGENT FOR DIARYL TEII SPECIES
– Tetrahedron Letters
(1980)
21,
1785
Synthesis of a substituted cis-decalin as a potential insect antifeedant
– Journal of the Chemical Society, Chemical Communications
(1979)
732
(doi: 10.1039/C39790000732)
Bis(p-methoxyphenyl) telluroxide: A new, mild oxidising agent
– Journal of the Chemical Society Chemical Communications
(1979)
755
(doi: 10.1039/C39790000755)
Isolation, Characterisation and Oxidation of Isomeric Ferrelactone Complexes.
– Journal of Organometallic Chemistry
(1979)
182,
c11
The crystal structure of 3-epicaryoptin and the reversal of the currently accepted absolute configuration of clerodin
– Chemical Communications
(1979)
97
(doi: 10.1039/C39790000097)
Preparation of episulphides from alkenes via succinimide-N-sulphenyl chloride or phthalimide-N-sulphenyl chloride adducts
– Journal of the Chemical Society, Perkin Transactions 1
(1979)
3013
(doi: 10.1039/p19790003013)
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