Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
THE SYNTHESIS AND DIELS-ALDER REACTIONS OF 2-PROP-2-ENYLIDENE-1,3-DIOXOLAN
– J. Chem. Soc., Perkin Trans. 1
(1981)
1582
(doi: 10.1039/p19810001582)
Oxygen atom transfer from iodylbenzene to diphenyl diselenide - a convenient method for dehydrogenation of steroidal 3-ketones
– Journal of the Chemical Society, Chemical Communications
(1981)
1044
(doi: 10.1039/C39810001044)
Synthesis of euryfuran, valdiviolide, and confertifolin
– Tetrahedron Letters
(1981)
22,
4747
Thermal decomposition of tricarbonyliron lactone complexes
– Journal of the Chemical Society, Chemical Communications
(1980)
299
(doi: 10.1039/c39800000299)
Selenium-mediated cyclization reactions of alkenyl-substituted β-ketoesters
– J. Chem. Soc., Chem. Commun.
(1980)
1173
(doi: 10.1039/C39800001173)
Oxidation of ketone and aldehyde hydrazones, oximes, and semicarbazones and of hydroxylamines and hydrazo-compounds, using benzeneseleninic anhydride
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1980)
1212
(doi: 10.1039/p19800001212)
Dehydrogenation of steroidal and triterpenoid ketones using benzeneseleninic anhydride
– Journal of the Chemical Society, Perkin Transactions 1
(1980)
2209
(doi: 10.1039/p19800002209)
Removal of thioacetal protecting groups by benzeneseleninic anhydride
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1980)
1654
(doi: 10.1039/p19800001654)
Chapter 13. Organosulphur, organoselenium, and organotellurium chemistry
– Annual Reports Section "B" (Organic Chemistry)
(1980)
77,
233
(doi: 10.1039/OC9807700233)
CATALYTIC-OXIDATION OF THIOCARBONYL COMPOUNDS INVOLVING THE USE OF 1,2-DIBROMOTETRACHLOROETHANE AS A BROMINATING REAGENT FOR DIARYL TEII SPECIES
– Tetrahedron Letters
(1980)
21,
1785
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