Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Cyclisation reactions of alkenyl β-ketoesters involving a novel phenylseleno group migration
Tetrahedron Letters
(1981)
22
2601
Preparation of lactones via tricarbonyliron–lactone complexes
J. Chem. Soc., Perkin Trans. 1
(1981)
270
(doi: 10.1039/p19810000270)
Diaryl telluroxides as new mild oxidising reagents
Tetrahedron
(1981)
37
213
(doi: 10.1016/0040-4020(81)85057-0)
Oxygen atom transfer from iodylbenzene to diphenyl diselenide - A convenient method for dehydrogenation of steroidal 3-ketones
Chemical Communications
(1981)
1044
(doi: 10.1039/c39810001044)
Selenium-mediated cyclization reactions of alkenyl-substituted β-ketoesters
Chemical Communications
(1980)
1173
(doi: 10.1039/c39800001173)
New cyclization procedure for alkenyl-substituted β-dicarbonyl compounds using N-phenylselenophthalimide
J. Chem. Soc., Chem. Commun.
(1980)
1028
(doi: 10.1039/C39800001028)
Thermal decomposition of tricarbonyliron lactone complexes
Journal of the Chemical Society, Chemical Communications
(1980)
299
(doi: 10.1039/c39800000299)
Organosulphur, organoselenium, and organotellurium chemistry
Annual Reports on the Progress of Chemistry Section B
(1980)
77
233
(doi: 10.1039/oc9807700233)
CATALYTIC-OXIDATION OF THIOCARBONYL COMPOUNDS INVOLVING THE USE OF 1,2-DIBROMOTETRACHLOROETHANE AS A BROMINATING REAGENT FOR DIARYL TEII SPECIES
Tetrahedron Letters
(1980)
21
1785
- ‹ previous
- Page 98
