Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

WITTIG AND HORNER-WITTIG COUPLING REACTIONS OF 2-SUBSTITUTED CYCLIC ETHERS AND THEIR APPLICATION TO SPIROKETAL SYNTHESIS

SV Ley, B Lygo, HM Organ, A Wonnacott

Tetrahedron

(1985)

3825

(doi: 10.1016/S0040-4020(01)91403-6)

Preparation of vinylic sulphones by Peterson olefination using phenyl trimethylsilylmethyl sulphone

D Craig, SV Ley, NS Simpkins, GH Whitham, MJ Prior

Journal of the Chemical Society Perkin Transactions 1

(1985)

1949

(doi: 10.1039/p19850001949)

SYNTHESIS OF THE NORTHERN HEMISPHERE OF THE MILBEMYCINS USING A NEW STRATEGY FOR THE FORMATION OF THE C-15 TO C-16 BOND

D Culshaw, P Grice, SV Ley, GA Strange

Tetrahedron Letters

(1985)

5837

(doi: 10.1016/S0040-4039(00)98940-8)

Total synthesis of the sesquiterpene (±)-hirsutene using an organoselenium-mediated cyclization reaction

SV Ley, PJ Murray, BD Palmer

Tetrahedron

(1985)

4765

(doi: 10.1016/s0040-4020(01)96715-8)

Synthesis of the β-lactam antibiotic (+)- thienamycin via an intermediate π-allyltricarbonyliron lactone complex

ST Hodgson, DM Hollinshead, SV Ley

Tetrahedron

(1985)

5871

(doi: 10.1016/S0040-4020(01)91426-7)

Structural reappraisal of the limonoid insect antifeedant azadirachtin

JN Bilton, HB Broughton, SV Ley, Z Lidert, ED Morgan, HS Rzepa, RN Sheppard

Journal of the Chemical Society Chemical Communications

(1985)

968

(doi: 10.1039/c39850000968)

Use of π-allyltricarbonyliron lactam complexes in the preparation of nocardicin derivatives: synthesis of (–)-3-oxo-1-[( p -benzyloxyphenyl)-benzyloxycarbonylmethyl]azetidin-2-one

ST Hodgson, DM Hollinshead, SV Ley, CMR Low, DJ Williams

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1985)

2375

(doi: 10.1039/P19850002375)

Fe2(co)g in tetrahydrofuran or under sonochemical conditions as convenient practical routes to π-allyltricarbonyliron lactone complexes

AM Horton, DM Hollinshead, SV Ley

Tetrahedron

(1984)

1737

(doi: 10.1016/S0040-4020(01)91124-X)

Oxo complexes of ruthenium(VI) and (VII) as organic oxidants

G Green, WP Griffith, DM Hollinshead, SV Ley, M Schröder

J CHEM SOC PERK T 1

(1984)

681

(doi: 10.1039/p19840000681)

Synthesis of spiroacetals using organoselenium-mediated cyclisation reactions. X -Ray molecular structure of (2 S ,8 R )-8-methyl-2-phenyl-1,7-dioxaspiro[5.5]undecan-4( R )-ol

AM Doherty, SV Ley, B Lygo, DJ Williams

Journal of the Chemical Society, Perkin Transactions 1

(1984)

1371

(doi: 10.1039/p19840001371)

Professor Steve Ley CBE FRS FMedSci

Director of Research

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