Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Use of π-allyltricarbonyliron lactam complexes in the preparation of nocardicin derivatives: synthesis of (–)-3-oxo-1-[(p-benzyloxyphenyl)-benzyloxycarbonylmethyl]azetidin-2-one
J CHEM SOC PERK T 1
(1985)
2375
(doi: 10.1039/p19850002375)
SYNTHETIC APPLICATIONS OF YNES, ENES AND ONES - ORGANOSELENIUM-MEDIATED CYCLIZATION REACTIONS IN ORGANIC-SYNTHESIS
CHEMISTRY & INDUSTRY
(1985)
101
SYNTHESIS OF THE NORTHERN HEMISPHERE OF THE MILBEMYCINS USING A NEW STRATEGY FOR THE FORMATION OF THE C-15 TO C-16 BOND
Tetrahedron Letters
(1985)
26
5837
Preparation of vinylic sulphones by Peterson olefination using phenyl trimethylsilylmethyl sulphone
J CHEM SOC PERK T 1
(1985)
1949
(doi: 10.1039/p19850001949)
PREPARATION AND REACTIONS OF 2-BENZENESULPHONYLTETRAHYDROPYRAN
Tetrahedron Letters
(1985)
26
535
Structural reappraisal of the limonoid insect antifeedant azadirachtin
Journal of the Chemical Society, Chemical Communications
(1985)
968
(doi: 10.1039/c39850000968)
The use of 3-acetoxy-1-trimethylsilylbutadiene in the synthesis of anthracyclinone derivatives
Journal of the Chemical Society Perkin Transactions 1
(1984)
1847
(doi: 10.1039/p19840001847)
A NEW ROUTE TO SPIRO-KETALS USING THE HORNER-WITTIG REACTION OF 2-DIPHENYLPHOSPHINOXY CYCLIC ETHERS
Tetrahedron Letters
(1984)
25
113
Synthesis of (±)-cis-6-methyltetrahydropyran-2-ylacetic acid, a natural product from viverra civetta. Using organoselenium-mediated cyclisation reactions
J. Chem. Soc., Perkin Trans. 1
(1984)
2403
(doi: 10.1039/P19840002403)
FE2(CO)9 IN TETRAHYDROFURAN OR UNDER SONOCHEMICAL CONDITIONS AS CONVENIENT PRACTICAL ROUTES TO PI-ALLYLTRICARBONYLIRON LACTONE COMPLEXES
Tetrahedron
(1984)
40
1737
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