Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Preparation of spiroketals by reaction of anions from 2-benzenesulphonyltetrahydropyrans with epoxides: synthesis of the c-11 to c-25 fragment of the milbemycins
Tetrahedron Letters
(1986)
27
5277
Synthetic approaches to the teleocidin-related tumour promoters: A total synthesis of (±)-indolactam V
Chemical Communications
(1986)
344
(doi: 10.1039/c39860000344)
Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes
Tetrahedron
(1986)
42
6519
Preparation of 2-substituted pyrroles and indoles by regioselective alkylation and deprotection of 1-(2-trimethylsilylethoxymethyl)pyrrole and 1-(2-trimethylsilylethoxymethyl) indole
Tetrahedron
(1986)
42
3723
Natural product synthesis using π-allyltricarbonyliron lactone complexes: Synthesis of parasorbic acid, the carpenter bee pheromone and malyngolide
Journal of Organometallic Chemistry
(1985)
285
C17
(doi: 10.1016/0022-328X(85)87394-0)
ORGANOSELENIUM-MEDIATED CYCLISATION REACTIONS IN ORGANIC SYNTHESIS.
Chemistry and Industry London
(1985)
101
Synthesis of the β-lactam antibiotic (+)- thienamycin via an intermediate π-allyltricarbonyliron lactone complex
Tetrahedron
(1985)
41
5871
Wittig and horner-wittig coupling reactions of 2-substituted cyclic ethers and their application to spiroketal synthesis
Tetrahedron
(1985)
41
3825
The use of t-butyl acetothioacetate as a route to bis-β-ketomacrolides
J. Chem. Soc., Chem. Commun.
(1985)
1805
(doi: 10.1039/C39850001805)
Total synthesis of the sesquiterpene (±)-hirsutene using an organoselenium-mediated cyclization reaction
Tetrahedron
(1985)
41
4765
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