Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
SV Ley, D Santafianos, WM Blaney, MSJ Simmonds
Tetrahedron Letters
(1987)
28
(doi: 10.1016/S0040-4039(00)95369-3)
CORRECTION
SV LEY
TETRAHEDRON LETTERS
(1987)
28
Preparation of acyltetronic acids using t-butyl acetothioacetate: total synthesis of the fungal metabolites carolic, carlosic, and carlic acids
PM Booth, CMJ Fox, SV Ley
Journal of the Chemical Society, Perkin Transactions 1
(1987)
(doi: 10.1039/p19870000121)
An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives
JN Bilton, HB Broughton, PS Jones, SV Ley, HS Rzepa, RN Sheppard, AMZ Slawin, DJ Williams, Z Lidert, ED Morgan
Tetrahedron
(1987)
43
(doi: 10.1016/S0040-4020(01)86886-1)
Application of ultrasound to the preparation of tricarbonyliron diene complexes
SV Ley, CMR Low, AD White
Journal of Organometallic Chemistry
(1986)
302
(doi: 10.1016/0022-328x(86)80072-9)
Ultrasonic formation and reactions of sodium phenylselenide
SV Ley, LA O'Neil, CMR Low
Tetrahedron
(1986)
42
(doi: 10.1016/S0040-4020(01)82086-X)
Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes
PS Jones, SV Ley, NS Simpkins, AJ Whittle
Tetrahedron
(1986)
42
(doi: 10.1016/S0040-4020(01)88114-X)
ALKYLATION REACTIONS OF ANIONS DERIVED FROM 2-BENZENESULFONYL TETRAHYDROPYRAN AND THEIR APPLICATION TO SPIROKETAL SYNTHESIS
SV Ley, B Lygo, F Sternfeld, A Wonnacott
Tetrahedron
(1986)
42
(doi: 10.1016/s0040-4020(01)87660-2)
PREPARATION OF 2-SUBSTITUTED PYRROLES AND INDOLES BY REGIOSELECTIVE ALKYLATION AND DEPROTECTION OF 1-(2-TRIMETHYLSILYLETHOXYMETHYL)PYRROLE AND 1-(2-TRIMETHYLSILYLETHOXYMETHYL) INDOLE
MP Edwards, AM Doherty, SV Ley, HM Organ
Tetrahedron
(1986)
42
(doi: 10.1016/s0040-4020(01)87342-7)
The synthesis of trisubstituted tetrahydrofurans via the use of an organoselenium-mediated cyclisation reaction
G Brussani, SV Ley, JL Wright, DJ Williams
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1986)
(doi: 10.1039/p19860000303)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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