Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
CORRECTION
TETRAHEDRON LETT
(1987)
28
1594
Application of ultrasound to the preparation of tricarbonyliron diene complexes
Journal of Organometallic Chemistry
(1986)
302
C13
(doi: 10.1016/0022-328x(86)80072-9)
X-Ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin
Chemical Communications
(1986)
1
46
(doi: 10.1039/C39860000046)
Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes
Tetrahedron
(1986)
42
6519
The synthesis of trisubstituted tetrahydrofurans via the use of an organoselenium-mediated cyclisation reaction
Journal of the Chemical Society Perkin Transactions 1
(1986)
303
(doi: 10.1039/p19860000303)
Ultrasonic formation and reactions of sodium phenylselenide
Tetrahedron
(1986)
42
5363
Alkylation reactions of anions derived from 2-benzenesulphonyl tetrahydropyran and their application to spiroketal syntiesis
Tetrahedron
(1986)
42
4333
Preparation of 2-substituted pyrroles and indoles by regioselective alkylation and deprotection of 1-(2-trimethylsilylethoxymethyl)pyrrole and 1-(2-trimethylsilylethoxymethyl) indole
Tetrahedron
(1986)
42
3723
Synthetic approaches to the teleocidin-related tumour promoters: A total synthesis of (±)-indolactam V
J. Chem. Soc., Chem. Commun.
(1986)
344
(doi: 10.1039/C39860000344)
SYNTHETIC STUDIES TOWARDS THE ACYLTETRONIC ACID IONOPHORE M-139603
Tetrahedron Letters
(1986)
27
105
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