Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Microbial oxidation in synthesis: A six step perparation of (+)-pinitol from benzene

SV Ley, F Sternfeld, S Taylor

Tetrahedron Letters

(1987)

28

225

(doi: 10.1016/S0040-4039(00)95692-2)

PREPARATION OF TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE AND USE IN THE SYNTHESIS OF (E)-4-ALKENYL-3-OXOESTERS AND MACROLIDES

SV Ley, PR Woodward

Tetrahedron Letters

(1987)

28

345

(doi: 10.1016/s0040-4039(00)95725-3)

The use of β-ketothioesters for the exceptionally mild preparation of β-ketoamides

SV Ley, PR Woodward

Tetrahedron Letters

(1987)

28

3019

(doi: 10.1016/s0040-4039(00)96273-7)

A CONFORMATIONAL STUDY OF BAFILOMYCIN-A1 BY X-RAY CRYSTALLOGRAPHY AND NMR TECHNIQUES

GH Baker, PJ Brown, RJJ Dorgan, JR Everett, SV Ley, AMZ Slawin, DJ Williams

Tetrahedron Letters

(1987)

28

5565

(doi: 10.1016/s0040-4039(00)96783-2)

Use of S -t-butyl acetothioacetate in the preparation of milbemycin seco-analogues

T Clarke, SV Ley

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1987)

131

(doi: 10.1039/p19870000131)

Preparation of acyltetronic acids using t-butyl acetothioacetate: total synthesis of the fungal metabolites carolic, carlosic, and carlic acids

PM Booth, CMJ Fox, SV Ley

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1987)

121

(doi: 10.1039/p19870000121)

Synthesis of the monocyclic nonaromatic C-1 to C-10 fragments of the milbemycins and avermectins.

NJ Anthony, T Clarke, AB Jones, SV Ley

Tetrahedron Letters

(1987)

28

5755

(doi: 10.1016/s0040-4039(00)96833-3)

SYNTHESIS OF A NOVEL 3,4-DIHYDROMILBEMYCIN ANALOG

C Greck, P Grice, AB Jones, SV Ley

Tetrahedron Letters

(1987)

28

5759

(doi: 10.1016/S0040-4039(00)96834-5)

An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives

JN Bilton, HB Broughton, PS Jones, SV Ley, HS Rzepa, RN Sheppard, AMZ Slawin, DJ Williams, Z Lidert, ED Morgan

Tetrahedron

(1987)

43

2805

(doi: 10.1016/S0040-4020(01)86886-1)

Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant

SV Ley, D Santafianos, WM Blaney, MSJ Simmonds

Tetrahedron Letters

(1987)

28

1595

(doi: 10.1016/s0040-4039(00)95369-3)