Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Organic synthesis with tricarbonyliron lactone complexes
SV Ley
Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences
(1988)
326
(doi: 10.1098/rsta.1988.0114)
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA INDICA .3. REACTIONS ON THE C-22,23 ENOL ETHER DOUBLE-BOND OF AZADIRACHTIN AND CONVERSION TO 22,23-DIHYDRO-23-BETA-METHOXYAZADIRACHTIN
SV Ley, JC Anderson, WM Blaney, Z Lidert, ED Morgan, NG Robinson, MSJ Simmonds
Tetrahedron Letters
(1988)
29
(doi: 10.1016/s0040-4039(00)82888-9)
PREPARATION OF TERT-BUTYL ACETOTHIOACETATE AND USE IN THE SYNTHESIS OF 3-ACETYL-4-HYDROXY-5,5-DIMETHYLFURAN-2(5H)-ONE
CMJ FOX, SV LEY
ORGANIC SYNTHESES
(1988)
66
Activity of drimane antifeedants and related compounds against aphids, and comparative biological effects and chemical reactivity of (−)- and (+)-polygodial
Y Asakawa, GW Dawson, DC Griffiths, JY Lallemand, SV Ley, K Mori, A Mudd, M Pezechk-Leclaire, JA Pickett, H Watanabe, CM Woodcock, Z Zhong-Ning
J Chem Ecol
(1988)
14
(doi: 10.1007/bf01013481)
1-BENZYLINDOLE
H HEANEY, SV LEY
ORG SYNTH
(1988)
50-9
Use of t-butyl 4-diethylphosphono-3-oxobutanethioate for tetramic acid synthesis: Total synthesis of the plasmodial pigment fuligorubin A
SV Ley, SC Smith, PR Woodward
Tetrahedron Letters
(1988)
29
(doi: 10.1016/S0040-4039(00)82204-2)
Chemistry of insect antifeedants from azadirachta indica (part 2): Synthesis of a polyoxygenated decalin with limonoid structural homology.
MG Brasca, HB Broughton, D Craig, SV Ley, AA Somovilla, PL Toogood
Tetrahedron Letters
(1988)
29
(doi: 10.1016/s0040-4039(00)82062-6)
Chemistry of insect antifeedants from (part 1): Conversion from the azadirachtin to the azadirachtinin skeletons
JN Bilton, PS Jones, SV Ley, NG Robinson, RN Sheppard
Tetrahedron Letters
(1988)
29
(doi: 10.1016/s0040-4039(00)82061-4)
PREPARATION OF CYCLIC ETHER ACETALS FROM 2-BENZENESULFONYL DERIVATIVES - A NEW MILD GLYCOSIDATION PROCEDURE
DS Brown, SV Ley, S Vile
Tetrahedron Letters
(1988)
29
(doi: 10.1016/S0040-4039(00)80631-0)
DIRECT SUBSTITUTION OF 2-BENZENESULFONYL CYCLIC ETHERS USING ORGANOZINC REAGENTS
DS Brown, SV Ley
Tetrahedron Letters
(1988)
29
(doi: 10.1016/S0040-4039(00)80630-9)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

Privacy and cookie policy

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge