Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A highly convergent total synthesis of the spiroacetal macrolide (+)-milbemycinβ1
Tetrahedron
(1989)
45
7161
PREPARATION OF O-METHYL 3-ACYL TETRONIC ACIDS BY THE DIRECT ACYLATION OF STANNYL TETRONATES
Tetrahedron Letters
(1989)
30
1001
THE STRUCTURE OF 2 NEW CLERODANE DITERPENOID POTENT INSECT ANTIFEEDANTS FROM SCUTELLARIA-WORONOWII (JUZ) - JODRELLIN-A AND JODRELLIN-B
Tetrahedron Letters
(1989)
30
4737
PREPARATION OF BETA-KETOMACROLACTONES AND BETA-KETODIOLIDES USING S-TERT-BUTYL 3-OXOBUTANETHIOATE AND S-TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE
Tetrahedron
(1989)
45
7565
Chemistry of insect antifeedants from azadirachta indica (part 4): synthesis towards the limonoid azadirachtin; preparation of a functionalised decalin fragment
Tetrahedron
(1989)
45
2143
ASSEMBLY OF THE T-CELL RECEPTOR CD3 COMPLEX
PROGRESS IN IMMUNOLOGY, VOL 7
(1989)
33
Substitution reactions of 2-benzenesulphonyl cyclic ethers with silyl enol ethers promoted by aluminium trichloride
Heterocycles
(1989)
28
773
(doi: 10.3987/com-88-s145)
TOTAL SYNTHESIS OF (+) - MILBEMYCIN BETA-1
Tetrahedron Letters
(1989)
30
3209
Microbial oxidation in synthesis: Preparation of 6-deoxy cyclitol analogues of myo-inositol 1,4,5-trisphosphate from benzene
Tetrahedron Letters
(1989)
30
3557
Organic synthesis with tricarbonyliron lactone complexes
Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences
(1988)
326
633
(doi: 10.1098/rsta.1988.0114)
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