Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
THE 1ST CRYSTAL AND MOLECULAR-STRUCTURE OF LANTHANIDE HOMODINUCLEAR MACROCYCLIC COMPLEXES SHOWING METAL METAL PAIR INTERACTIONS
Journal of the Chemical Society Chemical Communications
(1989)
1531
(doi: 10.1039/C39890001531)
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA INDICA .4. SYNTHESIS TOWARDS THE LIMONOID AZADIRACHTIN - PREPARATION OF A FUNCTIONALIZED DECALIN FRAGMENT
Tetrahedron
(1989)
45
2143
A highly convergent total synthesis of the spiroacetal macrolide (+)-milbemycinβ1
Tetrahedron
(1989)
45
7161
PREPARATION OF BETA-KETOMACROLACTONES AND BETA-KETODIOLIDES USING S-TERT-BUTYL 3-OXOBUTANETHIOATE AND S-TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE
Tetrahedron
(1989)
45
7565
Microbial oxidation in synthesis: Preparation of 6-deoxy cyclitol analogues of myo-inositol 1,4,5-trisphosphate from benzene
Tetrahedron Letters
(1989)
30
3557
TOTAL SYNTHESIS OF (+) - MILBEMYCIN BETA-1
Tetrahedron Letters
(1989)
30
3209
Preparation of O-methyl 3-acyl tetronic acids by the direct acylation of stannyl tetronates
Tetrahedron Letters
(1989)
30
1001
Substitution reactions of 2-benzenesulphonyl cyclic ethers with silyl enol ethers promoted by aluminium trichloride
Heterocycles
(1989)
28
773
(doi: 10.3987/com-88-s145)
ASSEMBLY OF THE T-CELL RECEPTOR CD3 COMPLEX
PROGRESS IN IMMUNOLOGY, VOL 7
(1989)
33
The antifeedant activity of clerodane diterpenoids from Teucrium
Phytochemistry
(1989)
28
1069
(doi: 10.1016/0031-9422(89)80184-0)
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