Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Chemistry of insect antifeedants from azadirachta indica (part 6): Synthesis of an optically pure acetal intermediate for potential use in the synthesis of azadirachtin and novel antifeedants.
Tetrahedron Letters
(1990)
31
431
Synthesis of a C16-C28 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a
Tetrahedron Letters
(1990)
31
3445
SYNTHESIS AND MODIFICATION OF AZADIRACHTIN AND RELATED ANTIFEEDANTS
RECENT ADVANCES IN THE CHEMISTRY OF INSECT CONTROL II
(1990)
79
90
DIRECT SUBSTITUTION OF 2-BENZENESULFONYLPIPERIDINES AND 2-BENZENESULFONYLPYRROLIDINES BY CARBON NUCLEOPHILES - SYNTHESIS OF THE PYRROLIDINE ALKALOID RUSPOLINONE
Synlett
(1990)
1990
48
(doi: 10.1055/s-1990-20983)
Enantioselective synthesis of the C3-C11 hydrocarbon fragment of the ionophore antibiotic tetronasin (ici 139603).
Tetrahedron Letters
(1990)
31
5521
Synthesis of the C12-C26 fragment of the acyltetronic acid lonophore antibiotic tetronasin (ici 139603)
Tetrahedron Letters
(1990)
31
5525
The structure of two new clerodane diterpenoid potent insect antifeedants from Scutellaria woronowii (Juz); jodrellin A & B
Tetrahedron Letters
(1989)
30
4737
Substitution reactions of 2-benzenesulphonyl cyclic ethers with carbon nucleophiles
Tetrahedron
(1989)
45
4293
INSECT ANTIFEEDANTS FROM AZADIRACHTA INDICA .5. CHEMICAL MODIFICATION AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF AZADIRACHTIN AND SOME RELATED LIMONOIDS
Tetrahedron
(1989)
45
5175
Microbial Oxidation in Synthesis: Preparation of (+)- and (-)-Pinitol from Benzene
Tetrahedron
(1989)
45
3463
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