Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Biosynthesis of tetronasin: Part 3 preparation of deuterium labelled tri- and tetraketides as putative biosynthetic precursors of tetronasin
Tetrahedron Letters
(1994)
35
315
Two new routes to the C19C26 tetrahydrofuran fragment of the acyl tetronic acid ionophore tetronasin (ICI M139603)
Tetrahedron Letters
(1994)
35
319
Biosynthesis of tetronasin: Part 1 introduction and investigation of the diketide and triketide intermediates bound to the polyketide synthase
Tetrahedron Letters
(1994)
35
307
BIOSYNTHESIS OF TETRONASIN .2. IDENTIFICATION OF THE TETRAKETIDE INTERMEDIATE ATTACHED TO THE POLYKETIDE SYNTHASE
Tetrahedron Letters
(1994)
35
311
Diastereoselective addition reactions to carbonyl groups in the side-chain of π-allytricarbonyliron lactone complexes
Chemical Communications
(1994)
1931
(doi: 10.1039/c39940001931)
Dispiroketals in synthesis (part 6): Highly stereoselective alkylation of dispiroketal protected lactate and glycolate enolates
Tetrahedron Letters
(1994)
35
769
TETRAPROPYLAMMONIUM PERRUTHENATE, PR4N+RUO4-, TPAP - A CATALYTIC OXIDANT FOR ORGANIC-SYNTHESIS
Synthesis
(1994)
1994
639
(doi: 10.1055/s-1994-25538)
Dispiroketals in synthesis (Part 17): Regioselective protection of D-glucopyranoside D-galactopyranoside and D-mannopyranoside substrates.
Tetrahedron Asymmetry
(1994)
5
2609
DISPIROKETALS IN SYNTHESIS .9. RESOLUTION OF 1,2-DIOLS USING A C-2-SYMMETRICAL DIPHENYLTETRAHYDROBIPYRAN
Tetrahedron Asymmetry
(1994)
5
553
(doi: 10.1016/0957-4166(94)80016-2)
DISPIROKETALS IN SYNTHESIS .15. SIMULTANEOUS ENANTIOSELECTIVE AND REGIOSELECTIVE PROTECTION OF GLYCEROL BY REACTION WITH C-2 SYMMETRICAL (4S,4'S)-DIMETHYL-BIS-DIHYDROPYRAN
Synthesis
(1994)
1994
1275
(doi: 10.1055/s-1994-25680)
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