Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Diastereoselective addition reactions to carbonyl groups in the side-chain of π-allytricarbonyliron lactone complexes

SV Ley, G Meek, K-H Metten, C Pique

Chemical Communications

(1994)

1931

(doi: 10.1039/C39940001931)

CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .17. SYNTHESIS OF MODEL COMPOUNDS OF AZADIRACHTIN - UNUSUAL EFFECT OF REMOTE SUBSTITUENTS ON THE COURSE OF THE OXIDATIVE RING CONTRACTION REACTION

RB Grossman, SV Ley

Tetrahedron

(1994)

50

11553

(doi: 10.1016/s0040-4020(01)89292-9)

"Connectivist" approach to organic structure determination Lsd-program assisted Nmr analysis of the insect antifeedant Azadirachtin

SV Ley, K Doberty, G Massiot, J-M Nuzillard

Tetrahedron

(1994)

50

12267

(doi: 10.1016/s0040-4020(01)89576-4)

DISPIROKETALS IN SYNTHESIS .9. RESOLUTION OF 1,2-DIOLS USING A C-2-SYMMETRICAL DIPHENYLTETRAHYDROBIPYRAN

PJ Edwards, DA Entwistle, SV Ley, DR Owen, EJ Perry

Tetrahedron Asymmetry

(1994)

5

553

(doi: 10.1016/0957-4166(94)80016-2)

Dispiroketals in synthesis (part 6): Highly stereoselective alkylation of dispiroketal protected lactate and glycolate enolates

R Downham, KS Kim, SV Ley, M Woods

Tetrahedron Letters

(1994)

35

769

(doi: 10.1016/S0040-4039(00)75813-8)

DISPIROKETALS IN SYNTHESIS .7. PROTECTION OF D-GLUCOPYRANOSE SUBSTRATES

AB Hughes, SV Ley, HWM Priepke, M Woods

Tetrahedron Letters

(1994)

35

773

(doi: 10.1016/s0040-4039(00)75814-x)

DISPIROKETALS IN SYNTHESIS .8. REGIOSELECTIVE PROTECTION OF D-GLUCOPYRANOSE SUBSTRATES

DA Entwistle, AB Hughes, SV Ley, G Visentin

Tetrahedron Letters

(1994)

35

777

(doi: 10.1016/s0040-4039(00)75815-1)

Selective Acylation and Alkylation Reactions of Diols Using Dibutyltin Dimethoxide

G-J Boons*, G Castle, J Clase, P Grice, S Ley, C Pinel

Synlett

(1993)

1993

913

(doi: 10.1055/s-1993-22650)

The chemistry of azadirachtin

SV Ley, AA Denholm, A Wood

Natural Product Reports

(1993)

10

109

(doi: 10.1039/NP9931000109)

Total synthesis of the spiroketal macrolide (+) milbemycin α1

SV Ley, A Madin, NJT Monck

Tetrahedron Letters

(1993)

34

7479

(doi: 10.1016/s0040-4039(00)60158-2)