Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Model studies towards the insect antifeedant Jodrellin A using an organoselenium mediated cyclization reaction
Tetrahedron Letters
(1994)
35
4861
Dispiroketals in synthesis (part 10): Further reactions of dispoke protected lactate and glycolate enolates
Tetrahedron
(1994)
50
7157
STUDIES TOWARDS THE TOTAL SYNTHESIS OF RAPAMYCIN - PREPARATION OF THE C10-C17 CARBON UNIT
Tetrahedron Letters
(1994)
35
2095
Studies towards the total synthesis of rapamycin: Preparation of the cyclohexyl C33C42 fragment and further coupling to afford the C22C42 carbon unit
Tetrahedron Letters
(1994)
35
2091
STUDIES TOWARDS THE TOTAL SYNTHESIS OF RAPAMYCIN - A CONVERGENT AND STEREOSELECTIVE SYNTHESIS OF THE C22-C32 CARBON FRAMEWORK
Tetrahedron Letters
(1994)
35
2087
Dispiroketals in synthesis (part 6): Highly stereoselective alkylation of dispiroketal protected lactate and glycolate enolates
Tetrahedron Letters
(1994)
35
769
Dispiroketals in synthesis (part 7): Protection of D-glucopyranose substrates
Tetrahedron Letters
(1994)
35
773
DISPIROKETALS IN SYNTHESIS .8. REGIOSELECTIVE PROTECTION OF D-GLUCOPYRANOSE SUBSTRATES
Tetrahedron Letters
(1994)
35
777
TOWARDS THE SYNTHESIS OF THE C-37-C-42 FRAGMENT OF RAPAMYCIN - INTRAMOLECULAR REACTIONS OF ALLYL SILANES WITH OXONIUM IONS GENERATED FROM ALPHA-ALKOXY SULFONES
Tetrahedron
(1994)
50
835
Novel polyene cyclisation routes to the acyl tetronic acid ionophore tetronasin (ICI M139603)
Tetrahedron Letters
(1994)
35
323
- ‹ previous
- Page 79
