Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

(1'S,2'S)-METHYL-3O,4O-(1',2'-DIMETHOXYCYCLOHEXANE-1',2'-DIYL)-a-D-MANNOPYRANOSIDE

SV Ley, HMI Osborn, HWM Priepke, SL Warriner, KA Scheidt, WR Roush

Organic Syntheses

(1998)

170

(doi: 10.15227/orgsyn.075.0170)

Studies towards the synthesis of the C29-C51 fragment of altohyrtin A

E Fernandez-Megia*, N Gourlaouen, SV Ley, GJ Rowlands

Synlett

(1998)

1998

991

(doi: 10.1055/s-1998-3140)

Tricarbonyliron complexes: an approach to acyclic stereocontrol

LR Cox, SV Ley

Chemical Society Reviews

(1998)

301

(doi: 10.1039/a827301z)

Enantioselective aldol reactions of α-unsubstituted enol ether derivatives catalyzed by a chiral Ti(IV) complex

SV Ley, LR Cox

Chemtracts

(1997)

853

Tetra-n-propylammonium perruthenate (TPAP)-catalysed oxidations of alcohols using molecular oxygen as a co-oxidant

R Lenz, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1997)

3291

(doi: 10.1039/a707339i)

1,5-Asymmetric induction of chirality: highly diastereoselective addition reactions of organoaluminium reagents into ketone groups in the side-chain of pi-allyltricarbonyliron lactone complexes

SV Ley, LR Cox, G Meek, K-H Metten, C Piqué, JM Worrall

J CHEM SOC PERK T 1

(1997)

3299

(doi: 10.1039/a704481j)

1,5-Asymmetric induction of chirality: diastereoselective addition of organoaluminium reagents and allylstannanes into aldehyclie groups in the side-chain of pi-allyltricarbonyliron lactone complexes

SV Ley, S Burckhardt, LR Cox, G Meek

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1997)

3327

(doi: 10.1039/a704487i)

1,5-Asymmetric induction of chirality: highly diastereoselective synthesis of homoallylic tertiary alcohols by the Lewis acid-mediated addition of allylstannanes into ketones in the side-chain of pi-allyltricarbonyliron lactone complexes

SV Ley, LR Cox

J CHEM SOC PERK T 1

(1997)

3315

(doi: 10.1039/a704491g)

Rapid access to rare natural pyranosides using 1,2-diacetal protected intermediates

SV Ley, DR Owen, KE Wesson

Journal of the Chemical Society Perkin Transactions 1

(1997)

2805

(doi: 10.1039/a705360f)

Direct preparation of diacetals from 1,2-diketones and their use as 1,2-diol protecting groups

A Hense, SV Ley, HMI Osborn, DR Owen, J-F Poisson, SL Warriner, KE Wesson

J CHEM SOC PERK T 1

(1997)

2023

(doi: 10.1039/a702497e)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

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