Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Chemistry of Insect Antifeedants from Azadirachta indica (Part 22): Functionalisation of the Decalin Fragment of Azadirachtin via a Claisen Rearrangement Reaction
Synlett
(1999)
1999
1295
(doi: 10.1055/s-1999-2802)
Tritiated dihydroazadirachtin binging to Schistocerca gregaria testes and Spodoptera Sf9 cells suggests a similar cellular mechanism of action for azadirachtin
AZADIRACHTA INDICA A. JUSS.
(1999)
247
Clean synthesis of a-bromo ketones and their utilisation in the synthesis of 2-aIkoxy-2,3-dihydro-2-aryl-l,4-benzodioxanes, 2-amino-4-aryI-l,3-thiazoles and piperidino-2-amino-l,3-thiazoles using polymer-supported reagents
Journal of the Chemical Society Perkin Transactions 1
(1999)
2425
(doi: 10.1039/a905616e)
Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents
Journal of the Chemical Society Perkin Transactions 1
(1999)
1253
(doi: 10.1039/a901802f)
Recent studies on the use of MPA and MTPA in the determination of the absolute configuration of secondary alcohols by 1H NMR
Chemtracts
(1999)
12
539
Nitrogen atom transfer from a novel nitridomanganese complex for the amination of silyl enol ether and glycal derivatives
Chemtracts
(1999)
12
27
Total synthesis of the protein phosphatase inhibitor okadaic acid
J CHEM SOC PERK T 1
(1998)
3907
(doi: 10.1039/a807957i)
Assembly of dendritic glycoclusters from monomeric mannose building blocks
Journal of the Chemical Society, Perkin Transactions 1
(1998)
3913
(doi: 10.1039/a807621i)
Characterization of azadirachtin binding to Sf9 nuclei in vitro
Archives of Insect Biochemistry and Physiology
(1998)
34
461
Total synthesis of roflamycoin, an oxopolyene macrolide antibiotic
Chemtracts
(1998)
11
1005
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