Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
New building blocks for efficient and highly diastereoselective polyol production—synthesis and utility of ( R ′, R ′, S , S ) and ( S ′, S ′, R , R )-2,3-butane diacetal protected butane tetrol derivatives
Journal of the Chemical Society Perkin Transactions 1
(1999)
1627
(doi: 10.1039/a902734c)
Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (pi-allyl)tricarbonyliron lactone complex
J CHEM SOC PERK T 1
(1999)
1917
(doi: 10.1039/a903641e)
Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents
Journal of the Chemical Society Perkin Transactions 1
(1999)
2421
(doi: 10.1039/a904384e)
Highly cis - or trans -selective oxygen to carbon rearrangements of anomerically linked 6-substituted tetrahydropyranyl enol ethers
J CHEM SOC PERK T 1
(1999)
2665
(doi: 10.1039/a904891j)
Total synthesis of the plasmoidal pigment physarorubinic acid, a polyenoyl tetramic acid
Journal of the Chemical Society Perkin Transactions 1
(1999)
2231
(doi: 10.1039/a904921e)
Clean synthesis of a-bromo ketones and their utilisation in the synthesis of 2-aIkoxy-2,3-dihydro-2-aryl-l,4-benzodioxanes, 2-amino-4-aryI-l,3-thiazoles and piperidino-2-amino-l,3-thiazoles using polymer-supported reagents
Journal of the Chemical Society Perkin Transactions 1
(1999)
2425
(doi: 10.1039/a905616e)
Chemistry of insect antifeedants from Azadirachta indica (Part 22):: Functionalisation of the decalin fragment of azadirachtin via a Claisen rearrangement reaction
Synlett
(1999)
1999
1295
(doi: 10.1055/s-1999-2802)
Prevalence of systemic hypertension in morbid obesity.: Polysomnographic study.
HYPERTENSION
(1999)
33
1076
Myocardial ischemia induced by obstructive sleep apnea in the hypertensive morbidly obese without known heart disease demonstrated by (SPECT) Tc 99m sestamibl preliminary report
HYPERTENSION
(1999)
33
1086
Prevalence of systemic hyprtension in morbid obesity.: Polysomnographic study.
HYPERTENSION
(1999)
33
1280
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