Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Prevalence of systemic hypertension in morbid obesity.: Polysomnographic study.
HYPERTENSION
(1999)
33
1076
Myocardial ischemia induced by obstructive sleep apnea in the hypertensive morbidly obese without known heart disease demonstrated by (SPECT) Tc 99m sestamibl preliminary report
HYPERTENSION
(1999)
33
1086
Actions of azadirachtin, a plant allelochemical, against insects
Pest Management Science
(1999)
54
277
Polymer-supported hypervalent iodine reagents in 'clean' organic synthesis with potential application in combinatorial chemistry
Journal of the Chemical Society Perkin Transactions 1
(1999)
669
(doi: 10.1039/a809799b)
Molybdenum(II)- and tungsten(II)-catalyzed allylic substitution
The Journal of organic chemistry
(1999)
64
2737
(doi: 10.1021/jo9821776)
Molybdenum(II)-catalyzed allylation of electron-rich aromatics and heteroaromatics
The Journal of Organic Chemistry
(1999)
64
2751
(doi: 10.1021/jo982178y)
1,7-Induction of chirality in Mukaiyama aldol reactions using π-allyltricarbonyliron lactone and lactam complexes as chiral templates
Tetrahedron
(1999)
55
3515
Chemical synthesis of the W-glycans of gp63, the major surface glycoprotein from Leishmania mexicana amazonemis
Journal of the Chemical Society, Perkin Transactions 1
(1999)
375
(doi: 10.1039/a809798d)
Clean five-step synthesis of an array of 1,2,3,4-tetra-substituted pyrroles using polymer-supported reagents
Journal of the Chemical Society, Perkin Transactions 1
(1999)
107
(doi: 10.1039/a809345h)
Rapid assembly of oligosaccharides: Total synthesis of a glycosylphosphatidylinositol anchor of Trypanosoma brucei
Angew Chem Int Ed Engl
(1999)
37
3423
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