Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

New building blocks for efficient and highly diastereoselective polyol production -: Synthesis and utility of (R′,R′,S,S) and (S′,S′,R,R)-2,3-butane diacetal protected butane tetrol derivatives

JS Barlow, DJ Dixon, AC Foster, SV Ley, DJ Reynolds

Journal of the Chemical Society Perkin Transactions 1

(1999)

1627

(doi: 10.1039/a902734c)

Dispiroketals in synthesis. Part 24.1 Preparation and use of chiral 2,2'-bis(triisopropylsiIyloxymethyl)bi(dihydropyran)s as new protecting and resolving agents for 1,2-diols

D Lainé, M Fujita, SV Ley

Journal of the Chemical Society, Perkin Transactions 1

(1999)

1639

(doi: 10.1039/a900950g)

Dispiroketals in synthesis.: Part 25.: Further reactions of dispiroketal protected glycolate to afford optically active 1,2,3,4-tetraols

M Fujita, D Lainé, SV Ley

J CHEM SOC PERK T 1

(1999)

1647

(doi: 10.1039/a900951e)

Preparation of desymmetrised meso-tartrate derivatives - synthesis and utility of (R ',R ',R,S)-2,3-butane diacetal protected dimethyl tartrate

DJ Dixon, AC Foster, SV Ley, DJ Reynolds

Journal of the Chemical Society, Perkin Transactions 1

(1999)

1631

(doi: 10.1039/a902733e)

Synthesis of the alkaloids (±)-oxomaritidine and (±)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents

SV Ley, O Schucht, AW Thomas, PJ Murray

Journal of the Chemical Society, Perkin Transactions 1

(1999)

1251

(doi: 10.1039/a901798d)

Prevalence of systemic hyprtension in morbid obesity.: Polysomnographic study.

M Fernández, V Rebollar, J Oseguera, A Orea, M Valencia, C Keirns, J Dorantes, M Reséndiz, M Rosales, R Campos, S Ley, X Gómez, J González-B, B García

HYPERTENSION

(1999)

1280

Myocardiac ischemia induced by obstructive sleep apnea in the hypertensive morbidly without known heart disease demonstrated by (SPECT) Te 99m sestamibl preliminary report

A Orea, V Rebollar, M Valencia, M Fernández, M Rosales, A Castaño, C Keirns, J Dorantes, J Sepulveda, S Ley, G García, J Oseguera, O González, J González

HYPERTENSION

(1999)

1303

Spect Tc 99m sestamibi in the evaluation of an an-tihypertensive drug (carvedilol) in heart failure (CHF) treatment.: Effect on coronary microcircula-tion

V Rebollar, Orea, M Fernández, J Dorantes, C Keirns, J Oseguera, A Rangel, J Sepulveda, S Ley, X Gómez, R Navarrete, T Sánchez, O González

HYPERTENSION

(1999)

1307

Total synthesis of the polyenoyltetramic acid mycotoxin erythroskyrine f

DJ Dixon, SV Ley, T Gracza, P Szolcsanyi

Journal of the Chemical Society Perkin Transactions 1

(1999)

839

(doi: 10.1039/a809823i)

Spect Tc 99m sestamibi in the evaluation of an an-tihypertensive drug (carvedilol) in the heart failure (CHF) treatment, effect on coronary microcircula-tion

V Rebollar, Orea, M Fernández, J Dorantes, C Keirns, J Oseguera, A Rangel, J Sepulveda, S Ley, X Gómez, R Navarrete, T Sánchez, O González

HYPERTENSION

(1999)

1088

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

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