Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Use of the Temporary Connection in Organic Synthesis

LR Cox, SV Ley

(1999)

274

(doi: 10.1002/9783527613526.ch10)

Highly cis- or fraws-selective oxygen to carbon rearrangements of anomerically linked 6-substituted tetrahydropyranyl enol ethers

DJ Dixon, SV Ley, EW Tate

Journal of the Chemical Society, Perkin Transactions 1

(1999)

2665

(doi: 10.1039/a904891j)

Modified mesoporous silicate MCM-41 materials: immobilised perruthenate - a new highly active heterogeneous oxidation catalyst for clean organic synthesis using molecular oxygen

A Bleloch, BFG Johnson, SV Ley, AJ Price, DS Shephard, AW Thomas

Chemical Communications

(1999)

1907

(doi: 10.1039/a906354d)

Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents

J Habermann, SV Ley, R Smits

J CHEM SOC PERK T 1

(1999)

2421

(doi: 10.1039/a904384e)

pi-allyltricarbonyliron lactone complexes in a diastereoselective Mukaiyama aldol reaction.

SVJ Ley, EA Wright

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(1999)

218

U51

Total synthesis of the plasmoidal pigment physarorubinic acid, a polyenoyl tetramic acid

DJ Dixon, SV Ley, DA Longbottom

Journal of the Chemical Society, Perkin Transactions 1

(1999)

2231

(doi: 10.1039/a904921e)

Use of the Potassium Ion as a Template for the Selective Derivatization of the Antibiotic X-206

AC O'Sulliva, F Struber, SV Ley

The Journal of Organic Chemistry

(1999)

6252

(doi: 10.1021/jo9903151)

Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (π-allyl)tricarbonyliron lactone complex

RW Bates, E Fernández-Megía, SV Ley, K Rück-Braun, DMG Tilbrook

Journal of the Chemical Society, Perkin Transactions 1

(1999)

1917

(doi: 10.1039/a903641e)

Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents

M Caldarelli, J Habermann, SV Ley

Bioorg Med Chem Lett

(1999)

2049

(doi: 10.1016/s0960-894x(99)00311-x)

A general and efficient procedure for the preparation of enantiopure anti -1,2-diols—synthesis and utility of ( R ′, R ′, S , R )-2,3-butane diacetal protected butane tetrol

DJ Dixon, AC Foster, SV Ley, DJ Reynolds

Journal of the Chemical Society, Perkin Transactions 1

(1999)

1635

(doi: 10.1039/a902732g)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

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