Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
New strategies for organic catalysis: The first highly enantioselective organocatalytic Diels-Alder reaction
Chemtracts
(2000)
13
592
Untitled - Comment
CHEMISTRY IN BRITAIN
(2000)
36
3
Membership changes - Reply
CHEMISTRY IN BRITAIN
(2000)
36
23
A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor CMI-977
Synthetic Communications
(2000)
30
1955
(doi: 10.1080/00397910008087245)
Asymmetric molybdenum-catalyzed allylic substitution.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2000)
219
U132
Preparation of desymmetrized meso-tartrate derivatives: Synthesis and utility of (R′,R′,R,-S)-2,3-butane diacetal protected dimethyl tartrate
Chemtracts
(2000)
13
66
1,2-Diacetals in synthesis: Total synthesis of a glycosylphosphatidylinositol anchor of Trypanosoma brucei
Chemistry - A European Journal
(1999)
6
172
Synthesis of Glycans from the Glycodelins: Two Undeca-, Two Deca-, Three Nona-, an Octa- and a Heptasaccharide
Chemistry A European Journal
(1999)
5
3326
Synthesis of Glycans from the Glycodelins: Two Undeca‐, Two Deca‐, Three Nona‐, an Octa‐ and a Heptasaccharide
Chemistry - A European Journal
(1999)
5
3326
- ‹ previous
- Page 66
