Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Deracemization of Baylis-Hillman adducts
Chemtracts
(2000)
13
596
A short and efficient stereoselective synthesis of the potent 5- lipoxygenase inhibitor CMI-977
Synthetic Communications
(2000)
30
1955
(doi: 10.1080/00397910008087245)
New strategies for organic catalysis: The first highly enantioselective organocatalytic Diels-Alder reaction
Chemtracts
(2000)
13
592
Tri-n-butyl[2-(trimethylsilyl)-ethoxymethoxymethyl]stannane: A Convenient Hydroxymethyl Anion Equivalent
Synlett
(2000)
2000
455
(doi: 10.1055/s-2000-6559)
Methyl 2,3-O-(6,6'-octahydro-6,6'-BI-2H-PYRAN-2,2'-DIYL)-α-D-galactopyranoside [ α-D-Galactopyranoside, methyl, 2,3-O-(octahydro[2,2'-bi-2H-pyran]-2,2'-diyl-, [2(2R,2'R)-] ]
Organic Syntheses
(2000)
77
212
(doi: 10.15227/orgsyn.077.0212)
Preparation of desymmetrized meso-tartrate derivatives: Synthesis and utility of (R′,R′,R,-S)-2,3-butane diacetal protected dimethyl tartrate
Chemtracts
(2000)
13
66
Clean and efficient synthesis of azo dyes using polymer-supported reagents
Green Chemistry
(2000)
2
43
(doi: 10.1039/b000816h)
1,2-diacetals in synthesis:: Total synthesis of a glycosylphosphatidylinositol anchor of Trypanosoma brucei
Chemistry
(1999)
6
172
Synthesis of Glycans from the Glycodelins: Two Undeca-, Two Deca-, Three Nona-, an Octa- and a Heptasaccharide
Chemistry A European Journal
(1999)
5
3326
Synthesis of glycans from the glycodelins: Two undeca-, two deca-, three nona-, an octa- and a heptasaccharide
Chemistry - A European Journal
(1999)
5
3326
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