Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Multi-step organic synthesis using solid-supported reagents and scavengers: A new paradigm in chemical library generation
Journal of the Chemical Society Perkin Transactions 1
(2000)
3815
(doi: 10.1039/b006588i)
Methyl 2,3-O-(6,6′-octahydro-6,6′-bi-2h-pyran-2,2′-diyl)-α-d- galactopyranoside: α-D-Galactopyranoside, methyl, 2,3-O-octahydro[2,2′-bi-2H-pyran]-2,2′-diyl-, [2(2R,2′R)-]
Organic Syntheses
(2000)
77
212
Diastereoselective oxygen to carbon rearrangements of anomerically linked enol ethers and the total synthesis of (+)-(S,S)-(cis-6-methyltetrahydropyran-2-yl)acetic acid, a component of civet
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2000)
2385
(doi: 10.1039/b001243m)
A Short Stereoselective Total Synthesis of the Fusarium Toxin Equisetin
Organic letters
(2000)
2
3611
(doi: 10.1021/ol006493u)
The total synthesis of the annonaceous acetogenin, muricatetrocin C
Angewandte Chemie International Edition
(2000)
39
3622
Chemoenzymatic synthesis of L-galactosylated dimeric sialyl Lewis X structures employing α-1,3-fucosyltransferase V
Bioorganic and Medicinal Chemistry
(2000)
8
2519
Membership changes - Reply
CHEMISTRY IN BRITAIN
(2000)
36
23
Polymer-supported reagents for multi-step organic synthesis: Application to the synthesis of sildenafil
Bioorg Med Chem Lett
(2000)
10
1983
Untitled - Comment
CHEMISTRY IN BRITAIN
(2000)
36
3
Combined Application of Analytical Techniques for the Characterization of Polymer Supported Species
J Comb Chem
(2000)
2
491
(doi: 10.1021/cc000021p)
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