Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
The Question of Delocalization in “Anchored” Ions with Potential Trishomoaromatic Character. 1. Reduction of Tricyclo[5.4.1.04,12]dodeca-2, 5, 8, 10-tetraene as a Route to the 10π11C Dianion
Journal of the American Chemical Society
(2002)
99
4756
(doi: 10.1021/ja00456a037)
Homotropylium-8-Sulfinate Complexes by SbF5-Promoted Ring Opening of 9-Thiabicyclo[4.2.1]nona-2,4,7-Triene and 9-Thiabarbaralane 9,9-Dioxides
Journal of the American Chemical Society
(2002)
98
152
(doi: 10.1021/ja00417a023)
Luminescence dynamics and 13C NMR characteristics of dinuclear complexes exhibiting coupled lanthanide(III) cation pairs
The Journal of Physical Chemistry
(2002)
96
7021
(doi: 10.1021/j100196a033)
Immobilization of thallium by tandem oxidation/reduction-complexation of thallium(I/III)
Inorganic Chemistry
(2002)
31
3963
(doi: 10.1021/ic00045a020)
Synthesis of trifluoromethyl ketones using polymer-supported reagents
Comb Chem High Throughput Screen
(2002)
5
197
(doi: 10.2174/1386207024607220)
Polyurea-encapsulated palladium(II) acetate: a robust and recyclable catalyst for use in conventional and supercritical media
Chem Commun (Camb)
(2002)
2
1134
(doi: 10.1039/b200677b)
Encapsulation of palladium in polyurea microcapsules
Chem Commun (Camb)
(2002)
10
1132
(doi: 10.1039/b200674j)
Analytical construct resins for analysis of solid-phase chemistry.
Chemistry (Weinheim an der Bergstrasse, Germany)
(2002)
8
The total synthesis of the annonaceous acetogenin, muricatetrocin C.
Chemistry (Weinheim an der Bergstrasse, Germany)
(2002)
8
Solid-supported reagents for multi-step organic synthesis: preparation and application
Il Farmaco
(2002)
57
321
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