Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
ALKALI-METAL REDUCTION STUDIES OF CIS-BICYCLO AND TRANS-BICYCLO[610]NONA-2,4,6-TRIENES IN LIQUID-AMMONIA - EVIDENCE FOR HIGH BASICITY OF MONOHOMOCYCLOOCTATETRAENE DIANIONS
Journal of the American Chemical Society
(2002)
96
6670
(doi: 10.1021/ja00828a021)
Tetracyanoethylene Addition to Iron Tricarbonyl Complexes of Substituted Cyclooctatetraenes. Regioselectivity Considerations during Formation of the 2,3,4,10-Tetrahapto Adducts
Journal of the American Chemical Society
(2002)
97
4658
(doi: 10.1021/ja00849a031)
A Facile Route to Imidazol-4-yl Anions and Their Reaction with Carbonyl Compounds
The Journal of Organic Chemistry
(2002)
56
5739
(doi: 10.1021/jo00020a002)
Total synthesis of the ionophore antibiotic X-14547A (Indanomycin)
The Journal of Organic Chemistry
(2002)
49
3503
(doi: 10.1021/jo00193a014)
Synthesis and Reducibility of Homo-2-methoxyazocines and Their Benzo-Fused Derivatives. An Examination of Heteroatomic Influences on the Possible Generation of 9C-10π Homoaromatic Dianions
The Journal of Organic Chemistry
(2002)
43
4712
(doi: 10.1021/jo00419a007)
Polyurea-encapsulated palladium(II) acetate: A robust and recyclable catalyst for use in conventional and supercritical media
Chemical communications (Cambridge, England)
(2002)
2
1134
(doi: 10.1039/b200677b)
Encapsulation of palladium in polyurea microcapsules.
Chemical communications (Cambridge, England)
(2002)
10
1132
(doi: 10.1039/b200674j)
Analytical construct resins for analysis of solid-phase chemistry.
Chemistry (Weinheim an der Bergstrasse, Germany)
(2002)
8
The total synthesis of the annonaceous acetogenin, muricatetrocin C.
Chemistry (Weinheim an der Bergstrasse, Germany)
(2002)
8
Solid-supported reagents for multi-step organic synthesis: preparation and application
Farmaco
(2002)
57
321
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