Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

NITROGEN ANALOGS OF 1,6-METHANO[12]ANNULENE - EFFECT ON VALENCE TAUTOMERISM OF LOCUS OF AZA SUBSTITUTION
LA Paquette, HC Berk, SV Ley
The Journal of Organic Chemistry
(2002)
40
(doi: 10.1021/jo00895a020)
Synthesis of trifluoromethyl ketones using polymer-supported reagents.
IR Baxendale, SV Ley, W Lumeras, M Nesi
Combinatorial Chemistry and High Throughput Screening
(2002)
5
(doi: 10.2174/1386207024607220)
Immobilization of Thallium by Tandem Oxidation/Reduction-Complexation of Thallium(I/III)
IA Kahwa, D Miller, M Mitchel, FR Fronczek, RG Goodrich, DJ Williams, CA O'Mahoney, AMZ Slawin, SV Ley, CJ Groombridge
Inorganic Chemistry
(2002)
31
(doi: 10.1021/ic00045a020)
LUMINESCENCE DYNAMICS AND C-13 NMR CHARACTERISTICS OF DINUCLEAR COMPLEXES EXHIBITING COUPLED LANTHANIDE(III) CATION PAIRS
KD Matthews, SA Bailey-Folkes, IA Kahwa, GL McPherson, CA O'Mahoney, SV Ley, DJ Williams, CJ Groombridge, CA O'Connor
Journal of Physical Chemistry
(2002)
96
(doi: 10.1021/j100196a033)
Homotropylium-8-sulfinate complexes by antimony pentafluoride-promoted ring opening of 9-thiabicyclo[4.2.1]nona-2,4,7-triene and 9-thiabarbaralane 9,9-dioxides
LA Paquette, U Jacobsson, SV Ley
Journal of the American Chemical Society
(2002)
98
(doi: 10.1021/ja00417a023)
Formation of monohomocyclooctatetraene dianions in liquid ammonia. Analysis of the nucleophilic reactivity of the cyclononatrienyl anions generated upon solvent protonation
LA Paquette, SV Ley, SG Traynor, JT Martin, JM Geckle
Journal of the American Chemical Society
(2002)
98
(doi: 10.1021/ja00441a046)
The question of delocalization in "anchored" ions with potential trishomoaromatic character. 1. Reduction of tricyclo[5.4.1.04,12]dodeca-2,5,8,10-tetraene as a route to the 10.pi.11C dianion
LA Paquette, MJ Kukla, SV Ley, SG Traynor
Journal of the American Chemical Society
(2002)
99
(doi: 10.1021/ja00456a037)
Thermal isomerization of homoazocines
GD Ewing, SV Ley, LA Paquette
Journal of the American Chemical Society
(2002)
100
(doi: 10.1021/ja00477a066)
An Efficient Synthesis of (-)-Triquinacene-2-carboxylic Acid
LA Paquette, SV Ley, WB Farnham
Journal of the American Chemical Society
(2002)
96
(doi: 10.1021/ja00808a081)
Directed syntheses of the isomeric dimethylcyclooctatetraenes and a study of their polarographic and alkali metal reduction
LA Paquette, SV Ley, RH Meisinger, RK Russell, M Oku
Journal of the American Chemical Society
(2002)
96
(doi: 10.1021/ja00825a019)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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