Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Formation of monohomocyclooctatetraene dianions in liquid ammonia. Analysis of the nucleophilic reactivity of the cyclononatrienyl anions generated upon solvent protonation
LA Paquette, SV Ley, SG Traynor, JT Martin, JM Geckle
Journal of the American Chemical Society
(2002)
98
(doi: 10.1021/ja00441a046)
Nitrogen Analogs of 1,6-Methano[12]annulene. Effect on Valence Tautomerism of the Locus of Aza Substitution
LA Paquette, HC Berk, SV Ley
The Journal of Organic Chemistry
(2002)
40
(doi: 10.1021/jo00895a020)
Synthesis and Reducibility of Homo-2-methoxyazocines and Their Benzo-Fused Derivatives. An Examination of Heteroatomic Influences on the Possible Generation of 9C-10π Homoaromatic Dianions
LA Paquette, GD Ewing, SV Ley, HC Berk, SG Traynor
Journal of Organic Chemistry
(2002)
43
(doi: 10.1021/jo00419a007)
TOTAL SYNTHESIS OF THE IONOPHORE ANTIBIOTIC X-14547A (INDANOMYCIN)
MP Edwards, SV Ley, SG Lister, BD Palmer, DJ Williams
Journal of Organic Chemistry
(2002)
49
(doi: 10.1021/jo00193a014)
A facile route to imidazol-4-yl anions and their reaction with carbonyl compounds
RM Turner, SD Lindell, SV Ley
Journal of Organic Chemistry
(2002)
56
(doi: 10.1021/jo00020a002)
Tetracyanoethylene addition to iron tricarbonyl complexes of substituted cyclooctatetraenes. Regioselectivity considerations during formation of the 2,3,4,10-tetrahapto adducts
LA Paquette, SV Ley, S Maiorana, DF Schneider, MJ Broadhurst, RA Boggs
Journal of the American Chemical Society
(2002)
97
(doi: 10.1021/ja00849a031)
ALKALI-METAL REDUCTION STUDIES OF CIS-BICYCLO AND TRANS-BICYCLO[610]NONA-2,4,6-TRIENES IN LIQUID-AMMONIA - EVIDENCE FOR HIGH BASICITY OF MONOHOMOCYCLOOCTATETRAENE DIANIONS
SV Ley, LA Paquette
Journal of the American Chemical Society
(2002)
96
(doi: 10.1021/ja00828a021)
Directed Syntheses of the Isomeric Dimethylcyclooctatetraenes and a Study of Their Polarographic and Alkali Metal Reduction
LA Paquette, SV Ley, RH Meisinger, RK Russell, M Oku
Journal of the American Chemical Society
(2002)
96
(doi: 10.1021/ja00825a019)
An Efficient Synthesis of (-)-Triquinacene-2-carboxylic Acid
LA Paquette, SV Ley, WB Farnham
Journal of the American Chemical Society
(2002)
96
(doi: 10.1021/ja00808a081)
Thermal Isomerization of Homoazocines
GD Ewing, SV Ley, LA Paquette
Journal of the American Chemical Society
(2002)
100
(doi: 10.1021/ja00477a066)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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