Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Total synthesis of Argyrin B.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2002)
224
U242
Application of analytical constructs to the development of an indole safety-catch linker family for solid phase organic synthesis.
ABSTR PAP AM CHEM S
(2002)
224
U175
Synthetic studies toward the total synthesis of Azadirachtin.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2002)
224
U242
Total synthesis of the amaryllidaceae alkaloid (+)-plicamine using solid-supported reagents
Tetrahedron
(2002)
58
6285
Total synthesis of polycephalin C and determination of the absolute configurations at the 3",4" ring junction.
Angew Chem Int Ed Engl
(2002)
41
2786
New tools and concepts for modern organic synthesis.
Nature reviews. Drug discovery
(2002)
1
573
(doi: 10.1038/nrd871)
A polymer-supported [1,3,2]oxazaphospholidine for the conversion of isothiocyanates to isocyanides and their subsequent use in an Ugi reaction
Bioorganic & medicinal chemistry letters
(2002)
12
1813
A concise synthesis of carpanone using solid-supported reagents and scavengers
J CHEM SOC PERK T 1
(2002)
2
1850
(doi: 10.1039/b203388g)
Synthesis of taurospongin A : a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using π-allyltricarbonyliron lactone complexes
Chemical Communications
(2002)
2
1624
(doi: 10.1039/b204994p)
Total Synthesis of the Amaryllidaceae Alkaloid (+)-Plicamine and Its Unnatural Enantiomer by Using Solid-Supported Reagents and Scavengers in a Multistep Sequence of Reactions We gratefully acknowledge financial support from Pfizer Central Research for a Postdoctoral Fellowship (to I.R.B.), the BP endowment and the Novartis Research Fellowship (to S.V.L.), and Pharmacia & Upjohn (to C.P.).
Angew Chem Int Ed Engl
(2002)
41
2194
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