Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Microwave assisted Leimgruber–Batcho reaction for the preparation of indoles , azaindoles and pyrroylquinolines

J Siu, IR Baxendale, SV Ley

Org Biomol Chem

(2003)

2

160

(doi: 10.1039/b313012f)

A Route to the Thapsigargins from (S)‐Carvone Providing a Substrate‐Controlled Total Synthesis of Trilobolide, Nortrilobolide, and Thapsivillosin F

SF Oliver, K Högenauer, O Simic, A Antonello, MD Smith, SV Ley

Angewandte Chemie (International ed. in English)

(2003)

42

5996

(doi: 10.1002/anie.200353140)

Enantioselective Synthesis of the Tetrahydrobenzylisoquinoline Alkaloid (-)-Norarmepavine Using Polymer Supported Reagents

R H. Perni, I R. Baxendale, T D. Davidson, S V. Ley

Heterocycles

(2003)

60

2707

(doi: 10.3987/com-03-9892)

Copper(I)-catalyzed preparation of (E)-3-iodoprop-2-enoic acid: (2-Propenoic acid, 3-iodo-, (2E)-)

DJ Dixon, SV Ley, DA Longbottom

Organic Syntheses

(2003)

80

129

The Use of Butane Diacetals of Glycolic Acid as Precursors for the Synthesis of the Phytotoxic Calmodulin Inhibitor Herbarumin II

E Díez, DJ Dixon, SV Ley, A Polara, F Rodríguez

Helvetica Chimica Acta

(2003)

86

3717

(doi: 10.1002/hlca.200390314)

The synthesis of the anti-malarial natural product polysphorin and analogues using polymer-supported reagents and scavengers

A-L Lee, SV Ley

Org Biomol Chem

(2003)

1

3957

(doi: 10.1039/b308761a)

Preparation of butane-1,2-diacetal-protected l-glyceraldehyde from D-mannitol

S Ley, P Michel

Synthesis

(2003)

2004

147

(doi: 10.1055/s-2003-42489)

A Practical and Efficient Synthesis of the C-16-C-28 Spiroketal Fragment (CD) of the Spongistatins

MJ Gaunt, DF Hook, HR Tanner, SV Ley

Org Lett

(2003)

5

4815

(doi: 10.1021/ol035848h)

Synthesis of the C-1-C-28 ABCD unit of spongistatin 1.

MJ Gaunt, AS Jessiman, P Orsini, HR Tanner, DF Hook, SV Ley

Org Lett

(2003)

5

4819

(doi: 10.1021/ol035849+)

Modern Synthetic Methods for Copper-Mediated C(aryl)-O, C(aryl)-N, and C(aryl)-S Bond Formation

SV Ley, AW Thomas

Angewandte Chemie International Edition

(2003)

42

5400

(doi: 10.1002/anie.200300594)