Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A highly automated, polymer-assisted strategy for the preparation of 2-alkylthiobenzimidazoles and N,N'-dialkylbenzimidazolin-2-ones.
Journal of combinatorial chemistry
(2005)
7
385
(doi: 10.1021/cc049832+)
Synthesis of a ceramide sphingolipid as a potential sex pheromone of the hair crab Erimacrus isenbeckii using butane-2,3-diacetal desymmetrised glycolic acid building blocks
Synlett
(2005)
481
(doi: 10.1055/s-2005-862361)
The total synthesis of the annonaceous acetogenin 10-hydroxyasimicin.
Angew Chem Int Ed Engl
(2005)
44
580
(doi: 10.1002/anie.200462264)
Supported Reagents and Scavengers in Multi-Step Organic Synthesis
(2005)
53
Total synthesis of the Fusarium toxin equisetin
Organic & biomolecular chemistry
(2004)
3
274
(doi: 10.1039/b411350k)
Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions.
Organic & Biomolecular Chemistry
(2004)
3
84
(doi: 10.1039/b414742a)
Studies on the generation of enolate anions from butane-2,3-diacetal protected glycolic acid derivatives and subsequent highly diastereoselective coupling reactions with aldehydes and acid chlorides
Organic and Biomolecular Chemistry
(2004)
2
3618
(doi: 10.1029/b412790k)
Preparation of enantiopure butane-2,3-diacetals of glycolic acid and alkylation reactions leading to alpha-hydroxyacid and amide derivatives.
Organic & Biomolecular Chemistry
(2004)
2
3608
(doi: 10.1039/b412788a)
The first Lewis acid-catalyzed allylboronate additions to aldehydes
Chemtracts
(2004)
17
620
Enantioselective organocatalytic cyclopropanation via ammonium ylides
Angewandte Chemie International Edition
(2004)
43
4641
(doi: 10.1002/anie.200460234)
- ‹ previous
- Page 47
