Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A sequential enantioselective, organocatalytic route to chiral 1,2-oxazines and chiral pyridazines
Org Biomol Chem
(2007)
5
2678
(doi: 10.1039/b708646f)
Natural Products as an Inspiration for the Discovery of New High‐Throughput Chemical Synthesis Tools
(2007)
2
51
(doi: 10.1002/9780470085226.ch18)
ORGN 121-Toward the total synthesis of azadirachtin
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2007)
234
Chiral Glycolate Equivalents for the Asymmetric Synthesis of α-Hydroxycarbonyl Compounds
Bulletin of the Chemical Society of Japan
(2007)
80
1451
(doi: 10.1246/bcsj.80.1451)
Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines.
Org Biomol Chem
(2007)
5
2758
(doi: 10.1039/b709043a)
Total Synthesis of Five Thapsigargins: Guaianolide Natural Products Exhibiting Sub‐Nanomolar SERCA Inhibition
Chemistry - A European Journal
(2007)
13
5688
(doi: 10.1002/chem.200700302)
Total synthesis of potent antifungal marine bisoxazole natural products bengazoles A and B
Chemistry - A European Journal
(2007)
13
5515
(doi: 10.1002/chem.200700033)
Pharmaceutical strategy and innovation: An academics perspective
Chemmedchem
(2007)
2
768
(doi: 10.1002/cmdc.200700008)
(S)- And (R)-5-Pyrrolidin-2-yl-1H-tetrazoles: Enantiomeric organocatalysts of broad utility in organic synthesis
Chimia
(2007)
61
247
(doi: 10.2533/chimia.2007.247)
Solid supported reagents in multi-step flow synthesis.
Ernst Schering Foundation Symposium Proceedings
(2007)
2006/3
151
(doi: 10.1007/2789_2007_033)
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