Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Primary Amides
GE Veitch, KL Bridgwood, SV Ley
Org Lett
(2008)
10
(doi: 10.1021/ol801398z)
A general organocatalytic enantioselective malonate addition to α,β-unsaturated enones
V Wascholowski, KR Knudsen, CET Mitchell, SV Ley
Chemistry A European Journal
(2008)
14
(doi: 10.1002/chem.200800673)
Practical organocatalysis with (S)- and (r)-5-pyrrolidin-2-yl-1H-tetrazoles
DA Longbottom, V Franckevicius, S Kumarn, AJ Oelke, V Wascholowski, SV Ley
Aldrichimica Acta
(2008)
41
New focused microwave approach to the synthesis of amino-substituted pyrroloisoquinolines and pyrroloquinolines via a sequential multi-component coupling process
S Ley, M Hopkin, I Baxendale
Synthesis
(2008)
2008
(doi: 10.1055/s-2008-1067048)
The application of focused microwave irradiation coupled with freeze drying to investigate the reaction of MgO and Al 2 O 3 slurries in the formation of layered double hydroxides
S Mitchell, IR Baxendale, W Jones
Green Chemistry
(2008)
10
(doi: 10.1039/b801365a)
Design of a specific oxidant for phenols
SD Barton, SV Ley
(2008)
(doi: 10.1002/9780470720349.ch5)
16th International Isotope Society (UK group) Symposium
G Åberg, FI Aigbirhio, E Alexakis, N Al‐Maharik, M Almi, Y Ambacher, S Andersson, A Athlan, G Badman, SA Baldwin, M Baumann, IR Baxendale, NP Botting, RA Bragg, JA Brown, A Burton, N Bushby, K Cable, G Campbell, R Carr, M Carroll, L Chen, M Christlieb, P Davies, GJ Ellames, W Ellis, C Elmore, T Fryatt, N Geach, JR Harding, S Hartmann, S Harwood, JJ Hayward, PJF Henderson, RB Herbert, JR Heys, S Hölzl, MD Hopkin, P Horn, T Ilyas, S Irvine, SD Jackson, J Jin, A Keats, AR Kennedy, WJ Kerr, MO Kitching, C Landreau, S Lanners, R Lawrence, KWM Lawrie, SV Ley, G Little, WJS Lockley, D Maier, C Manning, A McNeill, DA Middleton, S Montgomery, JJ Morrison, L Mrzljak, J Newman, J Newsome, N Nikbin‐Roudsari, GN Nilsson, MF Oldfield, SG Patching, DJ Procter, G Randall, AA Robertson, CS Rummel, D Rustidge, R Sherhod, N Shipley, CD Smith, CJ Smith, DI Smith, C Song, L Tamborini, I Waterhouse, A Watts, JL Werkheiser, G Williams, CL Willis, P Woodward, R Yan, G Young, Q Zhang
Journal of Labelled Compounds and Radiopharmaceuticals
(2008)
51
(doi: 10.1002/jlcr.1513)
A new synthesis of (-)-epipyriculol: a phytotoxic metabolite
A Leyva, FE Blum, SV Ley
Tetrahedron
(2008)
64
(doi: 10.1016/j.tet.2008.01.115)
FeCl 3 -Catalysed Cleavage of 1,2-Butanediacetal Protected Diols
S Ley, C Tzschucke, N Pradidphol, A Diéguez-Vázquez, B Kongkathip, N Kongkathip
Synlett
(2008)
2008
(doi: 10.1055/s-2008-1072752)
A general organocatalytic enantioselective nitrocyclopropanation reaction
S Ley, V Wascholowski, H Hansen, D Longbottom
Synthesis
(2008)
2008
(doi: 10.1055/s-2008-1042944)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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