University Associate Professor
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells
Science Advances
(2026)
12
eaec9801
(doi: 10.1126/sciadv.aec9801)
Length Scale-Dependent Dynamics in Electrostatic Protein Coacervates
(2026)
(doi: 10.64898/2026.03.27.714715)
Pushing the experimental resolution boundary in chromatin fibre organisation using multiscale simulations.
Curr Opin Genet Dev
(2026)
98
102464
(doi: 10.1016/j.gde.2026.102464)
Interplay between Local Diffusion, Concentration, and Inter-Protein Alignment Promotes Cross-β-Sheet Transitions at Condensate Interfaces
(2026)
(doi: 10.64898/2026.03.05.709844)
Condensate-Driven Transcriptional Reprogramming Defines Core Vulnerabilities in Esophageal and Gastric Cancers
(2026)
(doi: 10.64898/2026.02.23.707358)
Electrostatic control of chromatin compaction safeguards against apoptotic DNA release
(2026)
(doi: 10.64898/2026.02.23.707452)
A Goldilocks zone of DNA flexibility defines stable yet plastic nucleosomes, tuned by histone chemistry
(2026)
(doi: 10.64898/2026.02.16.706184)
Determination of Nucleotide–Nucleotide and Nucleotide–Amino Acid Binding Interactions from All-Atom Potential-of-Mean-Force Calculations
ACS Physical Chemistry Au
(2026)
6
308
Compositional Control of Aging Kinetics in TDP-43 Condensates
PRX Life
(2025)
3
043018
(doi: 10.1103/w7g3-6rsd)
Multiscale structure of chromatin condensates explains phase separation and material properties
Science
(2025)
390
eadv6588
(doi: 10.1126/science.adv6588)
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