University Associate Professor
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
Determination of nucleotide-nucleotide and nucleotide-amino acid binding interactions from all-atom potential-of-mean-force calculations
(2025)
(doi: 10.1101/2025.10.27.684844)
Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry
Nature Communications
(2025)
16
9296
(doi: 10.1038/s41467-025-64335-9)
Oct4 clusters promote DNA accessibility by enhancing chromatin plasticity
(2025)
(doi: 10.1101/2025.10.20.683403)
Predicting Saturation Concentrations of Phase-Separating Proteins via Thermodynamic Integration
J Chem Theory Comput
(2025)
21
9919
(doi: 10.1021/acs.jctc.5c00765)
Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross-β-sheet formation
Nature Communications
(2025)
16
8050
(doi: 10.1038/S41467-025-62686-X)
Nucleosome spacing can fine-tune higher-order chromatin assembly
Nat Commun
(2025)
16
6315
(doi: 10.1038/s41467-025-61482-x)
Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC
Nat Commun
(2025)
16
5550
(doi: 10.1038/s41467-025-60735-z)
Predicting Saturation Concentrations of Phase-Separating Proteins via Thermodynamic Integration
(2025)
(doi: 10.1101/2025.05.09.653068)
Charged mutations in the FUS low–complexity domain modulate condensate ageing kinetics
(2025)
(doi: 10.1101/2025.03.26.645197)
Analysis of long-range contacts across cell types outlines a core sequence determinant of 3D genome organisation
(2025)
(doi: 10.1101/2025.03.16.643527)
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