Wellcome Trust Fellow

Research

Dr Mateo Sanchez holds a Wellcome Trust Career Development Award in the Yusuf Hamied Department of Chemistry. His group works at the frontier between chemistry and biology. He aims to apply the principles of chemistry in order to unlock our understanding of cell biology and using biology to create new chemistry.  Specifically, he plans to develop new molecular tools leveraging optogenetics and protein engineering for cell biology and neuroscience. Another part of his research program will focus on the engineering of artificial metalloenzymes to catalyze new chemical reactions. 

Biography

Mateo Sanchez received his PhD in organic chemistry in 2014 from the University of Santiago de Compostela. The focus of his thesis was on the design and synthesis of fluorescent DNA binders.  In 2015, he joined the group of Professor Alice Ting at the Massachusetts Institute of Technology (MIT), and later in the Department of Genetics at Stanford University where he was awarded with an EMBO long-term postdoctoral fellowship. In 2020, Mateo joined the Synthetic Biology Centre in the Department of Bioengineering at Imperial College London, to work with Professor Tom Ellis to gain further expertise in synthetic biology. Mateo was awarded with a Marie-Curie Fellowship for a project involving the design of genetic circuits to study DNA repair mechanisms.

Now recruiting

Currently, we are hiring two postdoctoral researchers to start as soon as possible. We are looking for backgrounds in (1) organic synthesis, organometallic chemistry, chemical biology and (2) molecular biology, protein engineering, directed evolution, yeast genetics, and phage display. Please contact me for the time being at mis40@cam.ac.uk.

You can find out more about my research and publications on my web page.

Dr Sanchez Lopez discusses his research

Publications

Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates
J Mosquera, MI Sánchez, J Valero, J de Mendoza, ME Vázquez, JL Mascareñas
Chem Commun (Camb)
(2015)
51
Fluorescence-labeled bis-benzamidines as fluorogenic DNA minor-groove binders: photophysics and binding dynamics.
J Bordello, MI Sánchez, ME Vázquez, JL Mascareñas, W Al-Soufi, M Novo
Chemistry – A European Journal
(2014)
21
MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria
MI Sánchez, J Martínez-Costas, JL Mascareñas, ME Vázquez
ACS Chem Biol
(2014)
9
Ruthenium bipyridyl complexes as photocleavable dimerizers: deactivation of DNA-binding peptides using visible light
J Mosquera, MI Sánchez, ME Vázquez, JL Mascareñas
Chem Commun (Camb)
(2014)
50
Reversible Supramolecular Assembly at Specific DNA Sites: Nickel-Promoted Bivalent DNA Binding with Designed Peptide and Bipyridyl-Bis(benzamidine) Components
MI Sánchez, J Mosquera, ME Vázquez, JL Mascareñas
Angewandte Chemie (International ed. in English)
(2014)
53
Metal-catalyzed uncaging of DNA-binding agents in living cells†Electronic supplementary information (ESI) available: Synthesis and characterization of the studied molecules and required precursors. NMR, UV, and fluorescence spectra, titrations, control experiments, and detailed procedures for cell uptake and co-staining experiments. See DOI: 10.1039/c3sc53317dClick here for additional data file.
MI Sánchez, C Penas, ME Vázquez, JL Mascareñas
Chem Sci
(2014)
5
Custom-fit ruthenium(II) metallopeptides: a new twist to DNA binding with coordination compounds.
I Gamba, I Salvadó, G Rama, M Bertazzon, MI Sánchez, VM Sánchez-Pedregal, J Martínez-Costas, RF Brissos, P Gamez, JL Mascareñas, M Vázquez López, ME Vázquez
Chemistry – A European Journal
(2013)
19
Site-specific protein labeling using PRIME and chelation-assisted click chemistry
C Uttamapinant, MI Sanchez, DS Liu, JZ Yao, AY Ting
Nat Protoc
(2013)
8
Sequence-selective DNA recognition with peptide-bisbenzamidine conjugates.
MI Sánchez, O Vázquez, ME Vázquez, JL Mascareñas
Chemistry (Weinheim an der Bergstrasse, Germany)
(2013)
19
Single‐Molecule Approach to DNA Minor‐Groove Association Dynamics
J Bordello, MI Sánchez, ME Vázquez, JL Mascareñas, W Al-Soufi, M Novo
Angewandte Chemie (International ed. in English)
(2012)
51

Research Interest Groups

Telephone number

01223 336410 (shared)

Email address